ArticleMolecular and cellular biology1992
Mutations in a 19-amino-acid hydrophobic region of the yeast cytochrome c1 presequence prevent sorting to the mitochondrial intermembrane space.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Role for two conserved intermembrane space proteins, Ups1p and Ups2p, [corrected] in intra-mitochondrial phospholipid trafficking.The Journal of biological chemistry · 2012Article
- Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space.The EMBO journal · 2005Article
- Tim18p is a new component of the Tim54p-Tim22p translocon in the mitochondrial inner membrane.Molecular biology of the cell · 2000Article
- The N-terminal hydrophobic region of the mature phosphate translocator is sufficient for targeting to the chloroplast inner envelope membrane.The Plant cell · 1995Article
- A novel intermediate on the import pathway of cytochrome b2 into mitochondria: evidence for conservative sorting.The EMBO journal · 1995Article
- Import of cytochrome b2 to the mitochondrial intermembrane space: the tightly folded heme-binding domain makes import dependent upon matrix ATP.Protein science : a publication of the Protein Society · 1993Article
- MAS6 encodes an essential inner membrane component of the yeast mitochondrial protein import pathway.The Journal of cell biology · 1993Article
- Targeting of cytochrome b2 into the mitochondrial intermembrane space: specific recognition of the sorting signal.The EMBO journal · 1993Article
- The signal that sorts yeast cytochrome b2 to the mitochondrial intermembrane space contains three distinct functional regions.The EMBO journal · 1993Article
- Loss of mitochondrial hsp60 function: nonequivalent effects on matrix-targeted and intermembrane-targeted proteins.Molecular and cellular biology · 1993Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most mitochondrial proteins destined for the intermembrane space (IMS) carry in their presequence information for localization to the IMS in addition to information for their import. By selecting for mutants in the yeast Saccharomyces cerevisiae that mislocalize an IMS-targeted fusion protein, we identified mutations in the IMS sorting signal of the cytochrome c1 protein. Amino acid substitutions or deletions in a stretch of 19 hydrophobic amino acids of the cytochrome c1 presequence resulted in accumulation of the intermediate form of the cytochrome c1 protein in the matrix. In some cases, the accumulated intermediate appeared to be slowly exported from the matrix, across the inner membrane to the IMS. Our results support the hypothesis that the cytochrome c1 precursor is normally imported completely into the matrix and then exported to the IMS.
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Registered trials
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