ArticleJournal of molecular evolution1992
Pyrophosphate synthesis from phospho(enol)pyruvate catalyzed by precipitated magnesium phosphate with "enzyme-like" activity.
Article in Journal of molecular evolution, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Phosphates as Energy Sources to Expand Metabolic Networks.Life (Basel, Switzerland) · 2019Article
- The significance of Mg in prebiotic geochemistry.Geobiology · 2012Article
- Phosphate sorption and desorption on pyrite in primitive aqueous scenarios: relevance of acidic --> alkaline transitions.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2007Article
- Alkaline fluid circulation in ultramafic rocks and formation of nucleotide constituents: a hypothesis.Geochemical transactions · 2006Article
- Pyrite suspended in artificial sea water catalyzes hydrolysis of adsorbed ATP: enhancing effect of acetate.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1999Article
- Pyrophosphate and adenosine 5'-diphosphate synthesis from phospho(enol)pyruvate: catalysis by phosphate minerals and modulation by dimethyl sulfoxide.Journal of molecular evolution · 1997Article
- Reactions involving carbamyl phosphate in the presence of precipitated calcium phosphate with formation of pyrophosphate: a model for primitive energy-conservation pathways.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1995Article
- Adsorption of 5'-AMP and catalytic synthesis of 5'-ADP onto phosphate surfaces: correlation to solid matrix structures.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1995Article
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2 authors at 1 institution in 1 country.
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Abstract
The enzyme-like kinetic properties of precipitated magnesium phosphate as a catalyst for formation of pyrophosphate (PPi) from phospho(enol)pyruvate (PEP) are described. This synthesis occurs at a low temperature (37 degrees C) and represents a model that may help us understand the relevance to chemical evolution of minerals as ancient catalysts whose functions could have been taken over by contemporary enzymes. An insoluble Pi.Mg matrix was formed in a medium with 80% of the water replaced by dimethyl sulfoxide as a way of simulating conditions in a drying pond. Phospho(enol)pyruvate adsorbs onto the Pi.Mg surface according to a Langmuir isotherm, and the PEP concentration dependence of PPi formation follows a Michaelian-like function. A yield of 33% for transformation of the initially adsorbed PEP into PPi was attained after 4 days of incubation with equimolecular concentrations of Pi, MgCl2, and PEP. The magnesium concentration dependence for Pi and Mg precipitation, for adsorption of PEP onto solid Pi.Mg, and for PPi formation showed complex cooperative behavior. These results taken as a whole lead to the conclusion that the Pi.Mg surface not only provides a reactant for PPi formation but also catalyzes the reaction.
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