ArticleThe Journal of membrane biology1992
Slow inactivation of tetrodotoxin-insensitive Na+ channels in neurons of rat dorsal root ganglia.
Article in The Journal of membrane biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Functional role of Nav1.8 channels in action potentials of mouse CGRP-lineage dorsal root ganglion neurons.The Journal of physiology · 2026Article
- Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826.The Journal of general physiology · 2025Article
- Modulation of human dorsal root ganglion neuron firing by the Nav1.8 inhibitor suzetrigine.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Relationships between correlated spikes, oxygen and LFP in the resting-state primate.NeuroImage · 2022Article
- Dynamical Timescale Explains Marginal Stability in Excitability Dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The role of slow and persistent TTX-resistant sodium currents in acute tumor necrosis factor-α-mediated increase in nociceptors excitability.Journal of neurophysiology · 2015Article
- Repetitive activity slows axonal conduction velocity and concomitantly increases mechanical activation threshold in single axons of the rat cranial dura.The Journal of physiology · 2012Article
- Nociceptors are interleukin-1beta sensors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Conduction velocity is regulated by sodium channel inactivation in unmyelinated axons innervating the rat cranial meninges.The Journal of physiology · 2008Article
- Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons.The Journal of physiology · 2007Review
- Multiple types of Na(+) currents mediate action potential electrogenesis in small neurons of mouse dorsal root ganglia.Pflugers Archiv : European journal of physiology · 2006Article
- Role of tetrodotoxin-resistant Na+ current slow inactivation in adaptation of action potential firing in small-diameter dorsal root ganglion neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Selective expression of a persistent tetrodotoxin-resistant Na+ current and NaV1.9 subunit in myenteric sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Gating properties of Na(v)1.7 and Na(v)1.8 peripheral nerve sodium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Voltage-dependent neuromodulation of Na+ channels by D1-like dopamine receptors in rat hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Electrophysiological properties of sodium current subtypes in small cells from adult rat dorsal root ganglia.The Journal of physiology · 1998Article
- Single-channel analysis of two types of Na+ currents in rat dorsal root ganglia.Pflugers Archiv : European journal of physiology · 1995Article
- Slow sodium conductances of dorsal root ganglion neurons: intraneuronal homogeneity and interneuronal heterogeneity.Journal of neurophysiology · 1994Article
- Tetrodotoxin-resistant sodium channels.Cellular and molecular neurobiology · 1994Review
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Authors and funding
2 authors.
Funding
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Abstract
Whole-cell patch-clamp experiments were performed with neurons cultured from rat dorsal root ganglia (DRG). Two types of Na+ currents were identified on the basis of sensitivity to tetrodotoxin. One type was blocked by 0.1 nM tetrodotoxin, while the other type was insensitive to 10 microM tetrodotoxin. The peak amplitude of the tetrodotoxin-insensitive Na+ current gradually decreased after depolarization of the membrane. The steady-state value of the peak amplitude was attained several minutes after the change of holding potential. Such a slow inactivation was not observed in tetrodotoxin-sensitive Na+ current. The slow inactivation of the tetrodotoxin-insensitive Na+ current was kinetically distinct from the ordinary short-time "steady-state" inactivation. The voltage dependence of the slow inactivation could be described by a sigmoidal function, and its time course had a double-exponential process. A decrease of external pH partially antagonized the slow inactivation, probably through an increased diffusion potential across the membrane. However, the slow inactivation was not due to change in surface negative charges, since a shift of the kinetic parameters along the voltage axis was not observed during the slow inactivation. Due to the slow inactivation, the inactivation curves for the tetrodotoxin-insensitive Na+ current were shifted in the negative direction as the prepulse duration was increased. Consequently, the window current activated at potentials close to the resting membrane potential was markedly reduced. Thus, the slow inactivation may be involved in the long-term regulation of the excitability of sensory neurons.
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