ReviewThe Journal of membrane biology1992
Slow voltage inactivation of Ca2+ currents and bursting mechanisms for the mouse pancreatic beta-cell.
Review in The Journal of membrane biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Ultrafast multicellular calcium imaging of calcium spikes in mouse beta cells in tissue slices.Acta physiologica (Oxford, England) · 2025Article
- Deconstructing the integrated oscillator model for pancreatic β-cells.Mathematical biosciences · 2023Article
- Symbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells.Frontiers in physiology · 2021Review
- Closing in on the Mechanisms of Pulsatile Insulin Secretion.Diabetes · 2018Article
- Modeling K,ATP--dependent excitability in pancreatic islets.Biophysical journal · 2014Article
- Mathematical models of electrical activity of the pancreatic β-cell: a physiological review.Islets · 2014Review
- Ionic mechanisms and Ca2+ dynamics underlying the glucose response of pancreatic β cells: a simulation study.The Journal of general physiology · 2011Article
- Time-dependent changes in membrane excitability during glucose-induced bursting activity in pancreatic β cells.The Journal of general physiology · 2011Article
- Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms.American journal of physiology. Endocrinology and metabolism · 2010Review
- Modeling of the gap junction of pancreatic β-cells and the robustness of insulin secretion.Biophysics (Nagoya-shi, Japan) · 2010Article
- Electrical bursting, calcium oscillations, and synchronization of pancreatic islets.Advances in experimental medicine and biology · 2010Review
- Singular behavior of slow dynamics of single excitable cells.Biophysical journal · 2009Article
- The phantom burster model for pancreatic beta-cells.Biophysical journal · 2000Article
- Dynamical complexity and temporal plasticity in pancreatic beta-cells.Journal of biosciences · 2000Review
- Proximity oscillations of complement type 4 (alphaX beta2) and urokinase receptors on migrating neutrophils.Biophysical journal · 1997Article
- A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells.Biophysical journal · 1995Article
- Topological and phenomenological classification of bursting oscillations.Bulletin of mathematical biology · 1995Article
- Correlations of rates of insulin release from islets and plateau fractions for beta-cells.Bulletin of mathematical biology · 1995Article
- Estimating and eliminating junctional current in coupled cell populations by leak subtraction. A computational study.The Journal of membrane biology · 1995Article
- Anti-phase, asymmetric and aperiodic oscillations in excitable cells--I. Coupled bursters.Bulletin of mathematical biology · 1994Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent whole-cell electrophysiological data concerning the properties of the Ca2+ currents in mouse beta-cells are fitted by a two-current model of Ca2+ channel kinetics. When the beta-cell K+ currents are added to this model, only large modifications of the measured Ca2+ currents will reproduce the bursting pattern normally observed in mouse islets. However, when the measured Ca2+ currents are modified only slightly and used in conjunction with a K+ conductance that can be modulated dynamically by ATP concentration, reasonable bursting is obtained. Under these conditions it is the K-ATP conductance, rather than the slow voltage inactivation of the Ca2+ current, that determines the interburst interval. We find that this latter model can be reconciled with experiments that limit the possible periodic variation of the K-ATP conductance and with recent observations of intracellular Ca2+ bursting in islets.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.