ArticleThe Journal of cell biology1992
Inhibition of actin filament depolymerization by the Dictyostelium 30,000-D actin-bundling protein.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Quantum Dots Interaction with α-Actinin via Experimental Observations and Computational Predictions.International journal of molecular sciences · 2026Article
- De novo actin polymerization is required for model Hirano body formation in Dictyostelium.Biology open · 2016Article
- Septin 9 Exhibits Polymorphic Binding to F-Actin and Inhibits Myosin and Cofilin Activity.Journal of molecular biology · 2015Article
- Requirements for Hirano body formation.Eukaryotic cell · 2014Article
- A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.Molecular biology of the cell · 2012Article
- Roles of the espin actin-bundling proteins in the morphogenesis and stabilization of hair cell stereocilia revealed in CBA/CaJ congenic jerker mice.PLoS genetics · 2011Article
- Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium.Molecular biology of the cell · 2009Article
- Molecular and biochemical characterization of a novel actin bundling protein in Acanthamoeba.The Korean journal of parasitology · 2006Article
- Actin filament turnover regulated by cross-linking accounts for the size, shape, location, and number of actin bundles in Drosophila bristles.Molecular biology of the cell · 2003Article
- Growth cone collapse through coincident loss of actin bundles and leading edge actin without actin depolymerization.The Journal of cell biology · 2001Article
- Espin contains an additional actin-binding site in its N terminus and is a major actin-bundling protein of the Sertoli cell-spermatid ectoplasmic specialization junctional plaque.Molecular biology of the cell · 1999Article
- An invasion-associated Salmonella protein modulates the actin-bundling activity of plastin.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Small espin: a third actin-bundling protein and potential forked protein ortholog in brush border microvilli.The Journal of cell biology · 1998Article
- Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells.Molecular biology of the cell · 1998Article
- Supervillin (p205): A novel membrane-associated, F-actin-binding protein in the villin/gelsolin superfamily.The Journal of cell biology · 1997Article
- Dictyostelium discoideum cells lacking the 34,000-dalton actin-binding protein can grow, locomote, and develop, but exhibit defects in regulation of cell structure and movement: a case of partial redundancy.The Journal of cell biology · 1996Article
- The Dictyostelium cytoskeleton.Experientia · 1995Review
- Accumulation of actin in subsets of pioneer growth cone filopodia in response to neural and epithelial guidance cues in situ.The Journal of cell biology · 1993Article
- Focusing on unpolymerized actin.The Journal of cell biology · 1993Review
- Unexpected combinations of null mutations in genes encoding the actin cytoskeleton are lethal in yeast.Molecular biology of the cell · 1993Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have studied the effect of the Dictyostelium discoideum 30,000-D actin-bundling protein on the assembly and disassembly of pyrenyl-labeled actin in vitro. The results indicate that the protein is a potent inhibitor of the rate of actin depolymerization. The inhibition is rapid, dose dependent, and is observed at both ends of the filament. There is little effect of 30-kD protein on the initial rate of elongation from F-actin seeds or on the spontaneous nucleation of actin polymerization. We could detect little or no effect on the critical concentration. The novel feature of these results is that the filament ends are free for assembly but are significantly impaired in disassembly with little change in the critical concentration at steady state. The effects appear to be largely independent of the cross-linking of actin filaments by the 30-kD protein. Actin cross-linking proteins may not only cross-link actin filaments, but may also differentially protect filaments in cells from disassembly and promote the formation of localized filament arrays with enhanced stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.