ArticleBritish journal of pharmacology1992
Peripheral analgesic activities of peptides related to alpha-melanocyte stimulating hormone and interleukin-1 beta 193-195.
Article in British journal of pharmacology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 38 citations in OpenAlex.
- Adrenocorticotropic hormone: an effective "natural" biologic therapy for acute gout?Rheumatology international · 2020Review
- Structural modification of the tripeptide KPV by reductive "glycoalkylation" of the lysine residue.PloS one · 2018Article
- Interleukin-1β (187-207)-induced hyperthermia is inhibited by interleukin-1β (193-195) in rats.Neurochemical research · 2014Article
- Article
- Opioid peptides and opiate alkaloids in immunoregulatory processes.Archives of medical science : AMS · 2010Article
- Melanocortin peptides inhibit urate crystal-induced activation of phagocytic cells.Arthritis research & therapy · 2009Article
- Potent analgesic and anti-inflammatory actions of a novel thymulin-related peptide in the rat.British journal of pharmacology · 2002Article
- Alpha-melanocyte-related tripeptide, Lys-d-Pro-Val, ameliorates endotoxin-induced nuclear factor kappaB translocation and activation: evidence for involvement of an interleukin-1beta193-195 receptor antagonism in the alveolar epithelium.The Biochemical journal · 2001Article
- Involvement of the proinflammatory cytokines tumor necrosis factor-alpha, IL-1 beta, and IL-6 but not IL-8 in the development of heat hyperalgesia: effects on heat-evoked calcitonin gene-related peptide release from rat skin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Cytokine-mediated inflammatory hyperalgesia limited by interleukin-1 receptor antagonist.British journal of pharmacology · 2000Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The hyperalgesic effects of interleukin-1 beta (IL-1 beta) and prostaglandin E2 (PGE2) were measured in rats. 2. Hyperalgesic responses to IL-1 beta were inhibited in a dose-dependent manner by alpha-melanocyte stimulating hormone (alpha-MSH)-related peptides with the following order of potency: [N1(4),D-Phe7]alpha-MSH greater than alpha-MSH greater than Lys-D-Pro-Val greater than Lys-Pro-Val greater than Lys-D-Pro-Thr greater than D-Lys-Pro-Thr. 3. Hyperalgesic responses to PGE2 were not inhibited by Lys-D-Pro-Thr and D-Lys-Pro-Thr but were inhibited in a dose-dependent manner by the other peptides with the same order of potency as against IL-1 beta. 4. The potencies of [N1(4), D-Phe7]alpha-MSH and alpha-MSH were greatly diminished by deletion of their C-terminal tripeptide, Lys11-Pro-Val13. 5. Nor-binaltorphimine (Nor-BNI) largely reversed the analgesic effects of alpha-MSH, [N1(4), D-Phe7]alpha-MSH, Lys-Pro-Val and Lys-D-Pro-Val indicating that kappa-opioid receptors mediated the analgesic activity of these peptides. 6. Nor-BNI did not antagonize the inhibition by Lys-D-Pro-Thr and D-Lys-Pro-Thr of IL-1 beta evoked hyperalgesia indicating that these peptides were not acting via kappa-opioid receptors.
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