ReviewBritish journal of clinical pharmacology1992
Drugs acting on calcium channels: potential treatment for ischaemic stroke.
Review in British journal of clinical pharmacology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Efonidipine Exerts Cerebroprotective Effect by Down-regulation of TGF-β/SMAD-2-Dependent Signaling Pathway in Diabetic Rats.Journal of molecular neuroscience : MN · 2021Article
- Discovery and Development of Calcium Channel Blockers.Frontiers in pharmacology · 2017Review
- The role of glutamate in neuronal ischemic injury: the role of spark in fire.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2012Review
- Neuroprotective effects by nimodipine treatment in the experimental global ischemic rat model : real time estimation of glutamate.Journal of Korean Neurosurgical Society · 2011Article
- Molecular pharmacology of high voltage-activated calcium channels.Journal of bioenergetics and biomembranes · 2003Review
- Inhibition by lifarizine of intracellular Ca2+ rises and glutamate exocytosis in depolarized rat cerebrocortical synaptosomes and cultured neurones.British journal of pharmacology · 1996Article
- Neuroprotective efficacy of lifarizine (RS-87476) in a simplified rat survival model of 2 vessel occlusion.British journal of pharmacology · 1995Article
- Calcium, energy metabolism and the development of selective neuronal loss following short-term cerebral ischemia.Metabolic brain disease · 1995Review
- Reduction by lifarizine of the neuronal damage induced by cerebral ischaemia in rodents.British journal of pharmacology · 1995Article
- Regulation of the L-type calcium channel alpha-1 subunit by chronic depolarization in the neuron-like PC12 and aortic smooth muscle A7r5 cell lines.Pflugers Archiv : European journal of physiology · 1995Article
- Actions of the novel neuroprotective agent, lifarizine (RS-87476), on voltage-dependent sodium currents in the neuroblastoma cell line, N1E-115.British journal of pharmacology · 1995Article
- Block of human voltage-sensitive Na+ currents in differentiated SH-SY5Y cells by lifarizine.British journal of pharmacology · 1994Article
- The role of clinical pharmacology in the development and assessment of drugs for cerebrovascular disease and stroke.British journal of clinical pharmacology · 1993Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium subserves a ubiquitous role in the organisation of cell function. Ca2+ channels which control influx may be modified in disease states. Animal models of cerebral ischaemia do present some problems when investigating potential therapies involving Ca2+ channels. However, it is important not to be too rigid in searching for models which exactly mimic the human disease state, when even the best experimental approaches fall short of such an ideal. There are differences between different classes of calcium entry blocking drugs with regard to their activity on Ca2+ channels and transmembrane Ca2+ movement. Some calcium antagonists may also affect ion channels other than Ca2+, and this potential is exemplified by the novel ion channel modulator RS-87476, which affords experimental neurocytoprotection. Limitation of intracellular Na+ influx during ischaemia-induced depolarization may be useful.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.