ArticleProceedings of the National Academy of Sciences of the United States of America1992
Mitogen-expanded Schwann cells retain the capacity to myelinate regenerating axons after transplantation into rat sciatic nerve.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 62 citations in OpenAlex.
- Evaluation of peripheral nerve regeneration in Murphy Roths Large mouse strain following transection injury.Regenerative medicine · 2023Article
- αGlia · 2021Article
- Myelin sheath structure and regeneration in peripheral nerve injury repair.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Schwann cell-derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment.The Journal of clinical investigation · 2018Article
- Sustained Expression of Negative Regulators of Myelination Protects Schwann Cells from Dysmyelination in a Charcot-Marie-Tooth 1B Mouse Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- GPR56/ADGRG1 regulates development and maintenance of peripheral myelin.The Journal of experimental medicine · 2018Article
- The Pseudopod System for Axon-Glia Interactions: Stimulation and Isolation of Schwann Cell Protrusions that Form in Response to Axonal Membranes.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Article
- Gene therapy, CMT1X, and the inherited neuropathies.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Altered Trafficking and Processing of GALC Mutants Correlates with Globoid Cell Leukodystrophy Severity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin.The Journal of cell biology · 2015Article
- Kv7.2 regulates the function of peripheral sensory neurons.The Journal of comparative neurology · 2014Article
- Non-redundant function of dystroglycan and β1 integrins in radial sorting of axons.Development (Cambridge, England) · 2011Article
- Therapeutic strategies for the inherited neuropathies.Neuromolecular medicine · 2006Article
- Integration of engrafted Schwann cells into injured peripheral nerve: axonal association and nodal formation on regenerated axons.Neuroscience letters · 2005Article
- SRC-1 is involved in the control of the gene expression of myelin protein Po.Journal of molecular neuroscience : MN · 2004Article
- Expression of laminin receptors in schwann cell differentiation: evidence for distinct roles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Identification and characterization of early glial progenitors using a transgenic selection strategy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Promyelinating Schwann cells express Tst-1/SCIP/Oct-6.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Transplantation of an oligodendrocyte cell line leading to extensive myelination.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We have developed a method for genetically modifying Schwann cells (SCs) in vitro and then assessed whether these SCs could interact normally with axons in vivo. Rat SCs were transduced in vitro with the lacZ gene by using a retroviral vector and then expanded with the SC mitogens forskolin and glial growth factor. These mitogen-expanded SCs had an abnormal phenotype as compared to both SCs in vivo and primary SCs in vitro, yet when they were introduced into a regenerating rat sciatic nerve, they formed morphologically normal myelin sheaths around the axons. These results demonstrate that SCs can be genetically altered, their numbers expanded in culture, and yet respond appropriately to axonal signals in the peripheral nervous system. This approach offers a plausible way to manipulate genes involved in axon-SC interactions, including genes that may be defective in some inherited peripheral neuropathies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.