ArticleProceedings of the National Academy of Sciences of the United States of America1992
Chemotactic sorting to cAMP in the multicellular stages of Dictyostelium development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Article
- From environmental sensing to developmental control: cognitive evolution in dictyostelid social amoebas.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Intracellular ATP levels influence cell fates in Dictyostelium discoideum differentiation.Genes to cells : devoted to molecular & cellular mechanisms · 2020Article
- Tissue self-organization based on collective cell migration by contact activation of locomotion and chemotaxis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Collective cell migration ofCommunications biology · 2019Article
- Progress and perspectives in signal transduction, actin dynamics, and movement at the cell and tissue level: lessons fromInterface focus · 2016Review
- Article
- The green tea catechin epigallocatechin gallate (EGCG) blocks cell motility, chemotaxis and development in Dictyostelium discoideum.PloS one · 2013Article
- Evolution of developmental cyclic adenosine monophosphate signaling in the Dictyostelia from an amoebozoan stress response.Development, growth & differentiation · 2011Review
- Cell type-specific filamin complex regulation by a novel class of HECT ubiquitin ligase is required for normal cell motility and patterning.Development (Cambridge, England) · 2011Article
- Evolutionary crossroads in developmental biology: Dictyostelium discoideum.Development (Cambridge, England) · 2011Review
- Forming patterns in development without morphogen gradients: scattered differentiation and sorting out.Cold Spring Harbor perspectives in biology · 2009Review
- Acidic Ca2+ stores, excitability, and cell patterning in Dictyostelium discoideum.Eukaryotic cell · 2009Review
- Cell type specificity of a diffusible inducer is determined by a GATA family transcription factor.Development (Cambridge, England) · 2008Article
- Regulation of ammonia homeostasis by the ammonium transporter AmtA in Dictyostelium discoideum.Eukaryotic cell · 2007Article
- A model for cell type localization in the migrating slug of Dictyostelium discoideum based on differential chemotactic sensitivity to cAMP and differential sensitivity to suppression of chemotaxis by ammonia.Journal of biosciences · 2007Article
- Extracellular matrix family proteins that are potential targets of Dd-STATa in Dictyostelium discoideum.Journal of plant research · 2004Article
- Efficient system-wide coordination in noisy environments.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Ammonia differentially suppresses the cAMP chemotaxis of anterior-like cells and prestalk cells in Dictyostelium discoideum.Journal of biosciences · 2001Article
- A temperature-sensitive adenylyl cyclase mutant of Dictyostelium.The EMBO journal · 2000Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dictyostelium transformants that overproduce the extracellular form of cyclic nucleotide phosphodiesterase and so accumulate a reduced amount of cAMP are blocked in development after aggregation in the form of a tight mound, prior to formation of the apical tip. In such mounds, prespore cell differentiation is repressed, and the apical accumulation of prestalk cells is greatly retarded. When a source of cAMP is placed below the arrested mounds, prestalk cells that would normally migrate in an apical direction instead sort downwards to the substratum. Thus, by acting as the chemoattractant that draws prestalk cells to the apex, cAMP signaling directs the formation of a patterned structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.