ArticleProceedings of the National Academy of Sciences of the United States of America1992
Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 83 citations in OpenAlex.
- Multi-omics profiling reveals MAGEL2-driven defects in human corticogenesis shared across Prader-Willi and Schaaf-Yang syndromes.bioRxiv : the preprint server for biology · 2026Article
- BiallelicJournal of central nervous system disease · 2019Article
- Distribution and function of voltage-gated sodium channels in the nervous system.Channels (Austin, Tex.) · 2017Review
- A Common Polymorphism in SCN2A Predicts General Cognitive Ability through Effects on PFC Physiology.Journal of cognitive neuroscience · 2015Article
- Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures.Epilepsia · 2008Article
- Time-dependent molecular memory in single voltage-gated sodium channel.The Journal of membrane biology · 2007Article
- A nonsense mutation of the sodium channel gene SCN2A in a patient with intractable epilepsy and mental decline.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- A missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunction.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown resistance (kdr) to pyrethroid insecticides.Insect biochemistry and molecular biology · 2000Article
- Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.Biophysical journal · 2000Article
- 1H-NMR and circular dichroism spectroscopic studies on changes in secondary structures of the sodium channel inactivation gate peptides as caused by the pentapeptide KIFMK.Biophysical journal · 1999Article
- Isolation of the 5'-flanking region for human brain sodium channel subtype II alpha-subunit.Journal of molecular neuroscience : MN · 1998Article
- Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant German cockroaches (Blattella germanica) and house fly (Musca domestica).Molecular & general genetics : MGG · 1996Article
- Cloning of a sodium channel alpha subunit from rabbit Schwann cells.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Block of human voltage-sensitive Na+ currents in differentiated SH-SY5Y cells by lifarizine.British journal of pharmacology · 1994Article
- Targeted gene walking by low stringency polymerase chain reaction: assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Block of voltage-dependent sodium currents by the substance P receptor antagonist (+/-)-CP-96,345 in neurones cultured from rat cortex.British journal of pharmacology · 1993Article
- Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Structure, function and expression of voltage-dependent sodium channels.Molecular neurobiologyReview
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
Abstract
A cDNA library derived from human cerebral cortex was screened for the presence of sodium channel alpha subunit-specific clones. Ligation of three overlapping clones generated a full-length cDNA clone, HBA, that provided the complete nucleotide sequence coding for a protein of 2005 amino acids. The predicted structure suggests four homologous repeats and exhibits greatest homology and structural similarity to the rat brain sodium channel II. A second cDNA clone, HBB, that encodes a different subtype of sodium channel was isolated. Hybridization of DNA fragments from the 3' untranslated region of HBA and PCR with primers derived from HBB with human-hamster somatic cell hybrids localized these clones to human chromosome 2. In situ hybridization to human metaphase chromosomes mapped the structural genes for both HBA and HBB sodium channels to chromosome 2q23-24.3. The sodium channel HBA gene product was expressed by transfection in CHO cells. Expressed HBA currents were voltage-dependent, sodium-selective, and tetrodotoxin-sensitive and, thus, exhibit the biophysical and pharmacological properties characteristic of sodium channels.
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