ReviewCancer metastasis reviews1992
Autocrine motility factor and its receptor: role in cell locomotion and metastasis.
Review in Cancer metastasis reviews, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 91 citations in OpenAlex.
- Genetic Analysis of Two Novel GPI Variants Disrupting H Bonds and Localization Characteristics of 55 Gene Variants Associated with Glucose-6-phosphate Isomerase Deficiency.Current medical science · 2024Article
- Comprehensive Molecular Analyses of a Six-Gene Signature for Predicting Late Recurrence of Hepatocellular Carcinoma.Frontiers in oncology · 2021Article
- Autocrine motility factor and its receptor expression in musculoskeletal tumors.Journal of bone oncology · 2020Review
- Amplification of autocrine motility factor and its receptor in multiple myeloma and other musculoskeletal tumors.Journal of bone oncology · 2020Article
- Energy Metabolism in Cancer: The Roles of STAT3 and STAT5 in the Regulation of Metabolism-Related Genes.Cancers · 2020Review
- Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases.Frontiers in physiology · 2019Review
- Gp78 E3 Ubiquitin Ligase: Essential Functions and Contributions in Proteostasis.Frontiers in cellular neuroscience · 2017Review
- How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?Oncogene · 2015Review
- Metastasis-associated protein 1 drives tumor cell migration and invasion through transcriptional repression of RING finger protein 144A.The Journal of biological chemistry · 2012Article
- Enzymatic function of multiple origins regulates the progression of colorectal cancer and the development of metastases.Hippokratia · 2009Article
- Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions.Advances in immunology · 2006Review
- Identify lymphatic metastasis-associated genes in mouse hepatocarcinoma cell lines using gene chip.World journal of gastroenterology · 2005Article
- Regulation of cancer metastasis by stress pathways.Clinical & experimental metastasis · 2003Review
- Overexpression of autocrine motility factor receptor (AMFR) in NIH3T3 fibroblasts induces cell transformation.Clinical & experimental metastasis · 2003Article
- Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells.British journal of cancer · 2002Article
- Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function prediction.The Biochemical journal · 2000Article
- Regulation of E-cadherin: does hypoxia initiate the metastatic cascade?Molecular pathology : MP · 1999Review
- The crystal structure of a multifunctional protein: phosphoglucose isomerase/autocrine motility factor/neuroleukin.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Localization of autocrine motility factor receptor to caveolae and clathrin-independent internalization of its ligand to smooth endoplasmic reticulum.Molecular biology of the cell · 1998Article
- Tumor cell motility and metastasis : Autocrine motility factor as an example of ecto/exoenzyme cytokines.Pathology oncology research : POR · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The ability to locomote and migrate is fundamental to the acquisition of invasive and metastatic properties by tumor cells. Autocrine motility factor (AMF) is a 55 kD cytokine produced by various tumor cells which stimulates their in vitro motility and in vivo lung colonizing ability. AMF stimulates cell motility via a receptor-mediated signalling pathway. Signal transduction following binding of AMF to its receptor, a cell surface glycoprotein of 78 kD (gp78) homologous to p53, is mediated by a pertussis toxin sensitive G protein, inositol phosphate production and the phosphorylation of gp78. Cell surface gp78 is localized to the leading and trailing edges of motile cells but following cell permeabilization is found within an extended network of intracellular tubulovesicles. Gp78 tubulovesicles colocalize with microtubules and extension of the tubulovesicular network to the cell periphery is dependent on the presence of intact microtubules. Gp78 labeled vesicles can be induced to translocate between the cell center and periphery by altering intracellular pH as previously described for tubulovesicles labeled by fluid phase uptake. Anti-gp78 mAb added to viable motile cells is localized to large multivesicular bodies which, with time, relocate to the leading edge. Binding of AMF to its receptor induces signal transduction, similar to chemotactic stimulation of neutrophil mobility, as well as the internalization and transport of its receptor to the leading edge stimulating pseudopodial protrusion and cell motility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.