ArticleActa neuropathologica1992
Latent herpes simplex virus type 1 in human geniculate ganglia.
Article in Acta neuropathologica, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 92 citations in OpenAlex.
- Cognitive impairment without altered levels of cerebrospinal fluid biomarkers in patients with encephalitis caused by varicella-zoster virus: a pilot study.Scientific reports · 2020Trial
- Localization of annexin I (lipocortin I, p35) mRNA in normal and diseased human skin by in situ hybridization.Archives of dermatological research · 1996Trial
- Analytical review of facial nerve palsy following SARS-CoV-2 vaccination: comprehensive assessment.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Review
- Temperature-regulated type II grass carp reovirus establishes latent infection in Ctenopharyngodon idella brain.Virologica Sinica · 2023Article
- Bell's palsy and lip HSV-1 infection: importance of subcutaneous access.Journal of translational science · 2022Article
- A Review of Delayed Facial Nerve Paresis as Complication Following Total Endoscopic Ear Surgery.The journal of international advanced otology · 2021Review
- Association between Meniere's disease and air pollution in South Korea.Scientific reports · 2021Article
- Etiology and therapy of delayed facial paralysis after middle ear surgery.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020Review
- Herpes Infections and Dementia: Rebutting Alternative Fact.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Article
- Differential Involvement during Latent Herpes Simplex Virus 1 Infection of the Superior and Inferior Divisions of the Vestibular Ganglia: Implications for Vestibular Neuritis.Journal of virology · 2017Article
- Distribution of cellular HSV-1 receptor expression in human brain.Journal of neurovirology · 2017Article
- Increased risk of peripheral arterial occlusive disease in patients with Bell's palsy using population data.PloS one · 2017Article
- Review
- Delayed Facial Paralysis following Uneventful KTP Laser Stapedotomy: Two Case Reports and a Review of the Literature.Case reports in medicine · 2014Article
- Comparison of Transcranial Magnetic Stimulation and Electroneuronography Between Bell's Palsy and Ramsay Hunt Syndrome in Their Acute Stages.Annals of rehabilitation medicine · 2013Article
- Targeting herpetic keratitis by gene therapy.Journal of ophthalmology · 2012Article
- A cell culture model of facial palsy resulting from reactivation of latent herpes simplex type 1.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2012Article
- Control of HSV-1 latency in human trigeminal ganglia--current overview.Journal of neurovirology · 2011Review
- Bell's palsy: Treatment guidelines.Annals of Indian Academy of Neurology · 2011Article
- Herpes simplex virus type 1 and Bell's palsy-a current assessment of the controversy.Journal of neurovirology · 2010Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viral infection, especially by reactivation of herpes simplex virus (HSV) has been considered to be a possible explanation for the pathogenesis of idiopathic peripheral facial nerve palsy (Bell's palsy). We investigated whether the geniculate ganglia of man contain latent HSV type 1 (HSV-1), and compared the frequency of HSV-infected ganglia and that of latently infected neurons in human geniculate ganglia and in trigeminal ganglia. From autopsy specimens of eight adults 15 geniculate ganglia and 16 trigeminal ganglia were examined by means of in situ hybridization and immunohistochemical staining. The HSV-1 genome was detected in 11 of the 15 (71%) geniculate ganglia and in 13 of the 16 (81%) trigeminal ganglia. No HSV antigen was noted in any of the ganglia. The incidence of latently infected neurons was 0.9% in the trigeminal ganglia and 5.3% in the geniculate ganglia. The difference in percentages between the two types of ganglia was significant. Our results suggest that reactivation of latent HSV in the geniculate ganglia is a probable cause of some cases of herpetic stomatitis and of idiopathic peripheral facial nerve palsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.