ArticleJournal of virology1992
Hepadnavirus integration: mechanisms of activation of the N-myc2 retrotransposon in woodchuck liver tumors.
Article in Journal of virology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 82 citations in OpenAlex.
- Application of the woodchuck animal model for the treatment of hepatitis B virus-induced liver cancer.World journal of gastrointestinal oncology · 2021Review
- Host functions used by hepatitis B virus to complete its life cycle: Implications for developing host-targeting agents to treat chronic hepatitis B.Antiviral research · 2018Review
- Review
- Hepatocellular carcinoma.Cold Spring Harbor perspectives in medicine · 2015Review
- Hepatitis B and C virus hepatocarcinogenesis: lessons learned and future challenges.Cancer letters · 2011Review
- Liver cell transformation in chronic HBV infection.Viruses · 2009Article
- Detection of clonally expanded hepatocytes in chimpanzees with chronic hepatitis B virus infection.Journal of virology · 2009Article
- Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype.The American journal of pathology · 2008Article
- Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expression.Gene therapy · 2006Article
- Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Hepatocellular carcinoma in WHV/N-myc2 transgenic mice: oncogenic mutations of beta-catenin and synergistic effect of p53 null alleles.Oncogene · 2000Article
- Double-stranded linear duck hepatitis B virus (DHBV) stably integrates at a higher frequency than wild-type DHBV in LMH chicken hepatoma cells.Journal of virology · 1999Article
- Structure and glycosylation patterns of surface proteins from woodchuck hepatitis virus.Journal of virology · 1998Article
- In vivo effects of mutations in woodchuck hepatitis virus enhancer II.Journal of virology · 1998Article
- Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Woodchuck hepatitis virus enhancer I and enhancer II are both involved in N-myc2 activation in woodchuck liver tumors.Journal of virology · 1998Article
- pX, the HBV-encoded coactivator, suppresses the phenotypes of TBP and TAFII250 mutants.Genes & development · 1998Article
- Antisense downregulation of N-myc1 in woodchuck hepatoma cells reverses the malignant phenotype.Journal of virology · 1998Article
- Functional analysis of ground squirrel hepatitis virus enhancer II.Journal of virology · 1998Article
- p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53.The EMBO journal · 1998Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In persistent hepadnavirus infections, a distinctive feature of woodchuck hepatitis virus (WHV) is the coupling of frequent viral integrations into myc family genes with the rapid onset of primary liver tumors. We have investigated the patterns of WHV DNA insertion into N-myc2, a newly identified retroposed oncogene, in woodchuck hepatomas resulting from either natural or experimental infections. In both cases, integrated viral sequences were preferentially associated with the N-myc2 locus. In more than 40% of the woodchuck tumors analyzed, viral insertion sites were clustered in a 3-kb region upstream of N-myc2 or in the 3' noncoding region. Insertion of WHV sequences homologous to the human hepatitis B virus enhancers, either upstream or downstream of the N-myc2 coding domain, was associated with the production of normal N-myc2 mRNA or hybrid N-myc2-WHV transcripts, initiated at the normal N-myc2 transcriptional start site. Transient-transfection assays with different N-myc2-WHV constructs in HepG2 cells demonstrated that the viral enhancers could efficiently activate the N-myc2 promoter. These results, showing that cis activation of preferred cellular targets through enhancer insertion is a common strategy for tumor induction by WHV, emphasize the previously noted similarities between hepadnaviruses and nonacute oncogenic retroviruses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.