ArticleThe Journal of physiology1992
Calcium current variation between acutely isolated adult rat dorsal root ganglion neurons of different size.
Article in The Journal of physiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers.
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124 citing papers in PubMed, 349 citations in OpenAlex.
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- Central and peripheral contributions of T-type calcium channels in pain.Molecular brain · 2022Review
- Adverse effects of methylene blue in peripheral neurons: AnMolecular pain · 2022Article
- Animal Venom Peptides Cause Antinociceptive Effects by Voltage-gated Calcium Channels Activity Blockage.Current neuropharmacology · 2022Article
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- Cdk5-Dependent Phosphorylation of CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Spider Venom Peptide Pn3a Inhibition of Primary Afferent High Voltage-Activated Calcium Channels.Frontiers in pharmacology · 2020Article
- Inhibition of multiple voltage-gated calcium channels may contribute to spinally mediated analgesia by epipregnanolone in a rat model of surgical paw incision.Channels (Austin, Tex.) · 2019Article
- Ion Channels Involved in Tooth Pain.International journal of molecular sciences · 2019Review
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- Cryopreservation of Canine Primary Dorsal Root Ganglion Neurons and Its Impact upon Susceptibility to Paramyxovirus Infection.International journal of molecular sciences · 2019Article
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- Ablation of αProceedings of the National Academy of Sciences of the United States of America · 2018Article
64 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
1. The distribution of pharmacologically and/or biophysically unique Ca2+ current subtypes was studied in different diameter rat dorsal root ganglion (DRG) neuron cell bodies. DRG cells which fell into three diameter ranges, small (20-27 microns), medium (33-38 microns) and large (45-51 microns), were studied. T-type Ca2+ current was defined as low-threshold, rapidly inactivating current evoked by a weak test depolarization (-50 mV) from negative holding potentials (-80 to -100 mV), and which was sensitive to changes in holding potential. L-type Ca2+ current was defined as peak high-threshold Ca2+ current evoked from a holding potential of -60 mV and sensitive to blockade by 2 microM-nimodipine. N-type Ca2+ current was defined as peak high-threshold Ca2+ current evoked from a holding potential of -60 mV and sensitive to blockade by 0.9 microM-omega-conotoxin GVIA. 2. T-type Ca2+ currents were observed in small and medium diameter, but not in large diameter, DRG cell bodies. Large diameter DRG cell bodies had a small amount of low-threshold Ca2+ current but this current did not inactivate and was insensitive to a change in holding potential from -80 to -90 mV, and thus did not appear to be conducted through T-type Ca2+ channels. The T-type Ca2+ currents observed in medium diameter DRG cell bodies were considerably larger in amplitude (1-6 nA) than those observed in small diameter DRG cell bodies (100 pA-1 nA). This difference could not be accounted for by the difference in membrane surface area of small versus medium diameter DRG cell bodies. 3. The T-type Ca2+ currents observed in medium diameter DRG cells were sensitive to blockade by amiloride. Amiloride (500 microM) blocked 79.4 +/- 0.9% (mean +/- S.E.M.) of T-type Ca2+ current amplitude in six medium diameter DRG cell bodies which were held at -80 mV and depolarized to -50 or -40 mV. Amiloride (500 microM) failed to block high-threshold current in five medium diameter DRG cell bodies, indicating that it was specific for T-type Ca2+ current in these cells. 4. The percentage of peak whole-cell L-type Ca2+ current was significantly larger in small diameter DRG cell bodies (52.9 +/- 4.7% of total whole-cell Ca2+ current) than in medium diameter DRG cell bodies (6.6 +/- 3.9% of total whole-cell Ca2+ current) or large diameter DRG cell bodies (19.4 +/- 5.7% of total whole-cell Ca2+ current).(ABSTRACT TRUNCATED AT 400 WORDS)
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