ArticleProceedings of the National Academy of Sciences of the United States of America1992
Elimination of smooth muscle cells in experimental restenosis: targeting of fibroblast growth factor receptors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 133 citations in OpenAlex.
- Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression.EMBO molecular medicine · 2016Article
- Fibroblast growth factor receptor 4 polymorphism is associated with increased risk and poor prognosis of non-Hodgkin's lymphoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Fibroblast growth factor receptor 4 polymorphisms and the prognosis of non-Hodgkin lymphoma.Molecular biology reports · 2014Article
- Fibroblast growth factor receptor 4 polymorphisms and coronary artery disease: a case control study.Molecular biology reports · 2012Article
- Fibroblast growth factor receptor 4 polymorphisms and susceptibility to coronary artery disease.DNA and cell biology · 2012Article
- Vascular smooth cell proliferation in perfusion culture of porcine carotid arteries.Biochemical and biophysical research communications · 2008Article
- Expression and purification of cysteine introduced recombinant saporin.Protein expression and purification · 2008Article
- Regulation of fibroblast growth factor-2 expression in pulmonary arterial smooth muscle cells involves increased reactive oxygen species generation.American journal of physiology. Cell physiology · 2008Article
- Article
- The mechanisms of coronary restenosis: insights from experimental models.International journal of experimental pathology · 2000Review
- Butyrate inhibits proliferation-induced proliferating cell nuclear antigen expression (PCNA) in rat vascular smooth muscle cells.Molecular and cellular biochemistry · 2000Article
- Effect of fibroblast growth factor saporin mitotoxins on human bladder cell lines.Clinical & experimental metastasis · 1997Article
- Characterization of a saporin isoform with lower ribosome-inhibiting activity.The Biochemical journal · 1997Article
- Postnatal regulation of fibroblast growth factor ligand and receptor gene expression in rat thoracic aorta.The American journal of pathology · 1996Article
- Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia.The Journal of clinical investigation · 1996Article
- Serum stimulation, cell-cell interactions, and extracellular matrix independently influence smooth muscle cell phenotype in vitro.The American journal of pathology · 1996Article
- Transluminal angioplasty for arteriosclerotic disease of the distal vertebral and basilar arteries.Journal of neurology, neurosurgery, and psychiatry · 1996Article
- Amphotropic but not atherotropic: another caveat for adenoviral gene therapy.The Journal of clinical investigation · 1995Review
- Nitric oxide mediates cytotoxicity and basic fibroblast growth factor release in cultured vascular smooth muscle cells. A possible mechanism of neovascularization in atherosclerotic plaques.The Journal of clinical investigation · 1995Article
- Fibroblast growth factor stimulates angiotensin converting enzyme expression in vascular smooth muscle cells. Possible mediator of the response to vascular injury.The Journal of clinical investigation · 1995Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Factors in plasma and platelets do not fully account for the proliferation of smooth muscle cells in vascular injury, implying that additional factors are involved. Recently, we and others have observed that vascular injury regulates basic fibroblast growth factor, suggesting a further role for this pleiotropic factor. We report here that injury of rat arteries leads to an increase in fibroblast growth factor receptors in vascular smooth muscle cells. This up-regulation makes smooth muscle cells susceptible, in vitro and in vivo, to the lethal effects of a conjugate of basic fibroblast growth factor with the ribosome inactivator saporin. Saporin alone has no effect, whereas the conjugate kills proliferating, but not quiescent, smooth muscle cells in vitro. In vivo, one to three doses inhibit neointimal proliferation but have no apparent effect on the uninjured artery. Thus, the up-regulation of fibroblast growth factor receptors in vascular injury suggests new therapeutic possibilities for such refractory conditions as restenosis following balloon angioplasty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.