ArticleProceedings of the National Academy of Sciences of the United States of America1992
A single-stranded DNA-binding protein from Crithidia fasciculata recognizes the nucleotide sequence at the origin of replication of kinetoplast DNA minicircles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- Mitochondrial genome maintenance-the kinetoplast story.FEMS microbiology reviews · 2023Review
- UMSBP2 is chromatin remodeler that functions in regulation of gene expression and suppression of antigenic variation in trypanosomes.Nucleic acids research · 2023Article
- Direct monitoring of the stepwise condensation of kinetoplast DNA networks.Scientific reports · 2021Article
- Redox Balance Keepers and Possible Cell Functions Managed by Redox Homeostasis inFrontiers in cellular and infection microbiology · 2019Review
- Article
- Trypanosoma brucei UMSBP2 is a single-stranded telomeric DNA binding protein essential for chromosome end protection.Nucleic acids research · 2018Article
- A comparative molecular and 3-dimensional structural investigation into cross-continental and novel avian Trypanosoma spp. in Australia.Parasites & vectors · 2017Article
- TAC102 Is a Novel Component of the Mitochondrial Genome Segregation Machinery in Trypanosomes.PLoS pathogens · 2016Article
- Universal minicircle sequence binding protein of Leishmania donovani regulates pathogenicity by controlling expression of cytochrome-b.Cell & bioscience · 2016Article
- Interactions of a replication initiator with histone H1-like proteins remodel the condensed mitochondrial genome.The Journal of biological chemistry · 2011Article
- Regulation of UMSBP activities through redox-sensitive protein domains.Nucleic acids research · 2009Article
- Mitochondrial origin-binding protein UMSBP mediates DNA replication and segregation in trypanosomes.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Redox potential regulates binding of universal minicircle sequence binding protein at the kinetoplast DNA replication origin.Eukaryotic cell · 2004Article
- Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library.The EMBO journal · 2002Article
- From the cell biology to the development of new chemotherapeutic approaches against trypanosomatids: dreams and reality.Kinetoplastid biology and disease · 2002Article
- Intramitochondrial localization of universal minicircle sequence-binding protein, a trypanosomatid protein that binds kinetoplast minicircle replication origins.The Journal of cell biology · 2001Article
- Nucleus-encoded histone H1-like proteins are associated with kinetoplast DNA in the trypanosomatid Crithidia fasciculata.Molecular and cellular biology · 1996Article
- A single-stranded DNA binding protein binds the origin of replication of the duplex kinetoplast DNA.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Control of gene expression in trypanosomes.Microbiological reviews · 1995Review
- ST-1, a 39-kilodalton protein in Trypanosoma brucei, exhibits a dual affinity for the duplex form of the 29-base-pair subtelomeric repeat and its C-rich strand.Molecular and cellular biology · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A sequence-specific single-stranded DNA-binding protein from the trypanosomatid protozoan Crithidia fasciculata binds to a sequence of 12 nucleotides located at the origin of replication of kinetoplast DNA minicircles. This sequence, termed the universal minicircle sequence (UMS), is conserved in the kinetoplast DNA minicircles among species of the family Trypanosomatidae. The purified protein binds specifically to the heavy strand of the DNA at this site, which consists of the sequence 5'-GGGGTTGGTGTA-3'. Binding analyses using mutated UMS dodecamers have revealed the significant contribution of each of the individual residues at the binding site, with the exception of the 3'-terminal adenine residue, to the generation of specific protein-DNA complexes. The possible role of this sequence-specific single-stranded DNA-binding protein in replication of kinetoplast DNA minicircles and the relation of the UMS to chromosomal telomeric sequences are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.