ArticleThe Journal of clinical investigation1992
Release of soluble receptors for tumor necrosis factor (TNF) in relation to circulating TNF during experimental endotoxinemia.
Article in The Journal of clinical investigation, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 232 citations in OpenAlex.
- Prediagnostic serum levels of cytokines and other immune markers and risk of non-hodgkin lymphoma.Cancer research · 2011Trial
- Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects.Intensive care medicine · 2007Trial
- Influence of pentoxifylline on cytokine levels and inflammatory parameters in septic shock.Intensive care medicine · 1996Trial
- Plasma endotoxin and cytokine levels in neutropenic and non-neutropenic bacteremic patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1995Trial
- Relationship between soluble tumor necrosis factor (TNF) receptors and TNF alpha during immunotherapy with interleukin-2 and/or interferon alpha.Cancer immunology, immunotherapy : CII · 1994Trial
- Soluble TNF receptors predict acute kidney injury and mortality in critically ill COVID-19 patients: A prospective observational study.Cytokine · 2022Observational
- Estrogen-Related Receptor γ Agonist DY131 Ameliorates Lipopolysaccharide-Induced Acute Liver Injury.Frontiers in pharmacology · 2021Article
- Altered Monocyte and Endothelial Cell Adhesion Molecule Expression Is Linked to Vascular Inflammation in Human Immunodeficiency Virus Infection.Open forum infectious diseases · 2016Article
- Expression levels of tumor necrosis factor-α and the corresponding receptors are correlated with trauma severity.Oncology letters · 2014Article
- Polymorphisms in the tumor necrosis factor receptor genes affect the expression levels of membrane-bound type I and type II receptors.Mediators of inflammation · 2014Article
- Inflammatory biomarkers and emotional approach coping in men with prostate cancer.Brain, behavior, and immunity · 2013Article
- Baseline TNFα operational capacity in fetal and maternal circulation prior to the onset of labor: "tuned for different purposes".Reproductive sciences (Thousand Oaks, Calif.) · 2013Article
- Use of inflammatory molecules to predict the occurrence of fever in onco-hematological patients with neutropenia.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Observational
- Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C.International journal of hepatology · 2013Article
- Cytokines in sepsis: potent immunoregulators and potential therapeutic targets--an updated view.Mediators of inflammation · 2013Review
- Measurement of tumour necrosis factor receptors for immune response in colon cancer patients.Clinical and experimental medicine · 2012Article
- Soluble inflammatory markers as predictors of liver histological changes in patients with chronic hepatitis C virus infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2010Article
- Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2009Article
- Effect of intestinal microflora on the production of interleukin 10 and prostaglandin e(2) in serum and kupffer cells from germfree and conventional mice.Journal of clinical biochemistry and nutrition · 2007Article
- Both Th1- and Th2-derived cytokines in serum are elevated in Graves' ophthalmopathy.Clinical and experimental immunology · 2000Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serial plasma samples from human volunteers obtained after intravenous administration of Escherichia coli endotoxin were analyzed for the presence of circulating soluble tumor necrosis factor receptors (sTNFR). A four- to fivefold increase of type A (p75) and type B (p55) sTNFR was observed 3 h after endotoxin challenge. Pretreatment of the volunteers with ibuprofen before the injection of endotoxin resulted in a slight increase (3.87 +/- 0.2 vs. 3.27 +/- 0.3 ng/ml) and temporal shift of sTNFR-A release concurrent to a marked augmentation of TNF levels (603 +/- 118 vs. 338 +/- 56 pg/ml) as compared to the group without ibuprofen pretreatment. There was a significant correlation between peak sTNFR-A levels and peak TNF levels in the individual probands (r = 0.52, P = 0.04). On the contrary, release kinetics and plasma concentrations of sTNFR-B were identical in both groups (7.38 +/- 0.69 vs. 7.44 +/- 0.33 ng/ml) and no correlation with individual TNF levels was observed. The amount of sTNFR liberated upon endotoxin challenge was not sufficient to block TNF-mediated cytotoxic effects. Our data indicate that the release in vivo of type A and type B sTNFR upon a short exposure to endotoxin is regulated differently.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.