ArticleThe Journal of clinical investigation1992
Activin and inhibin in the human adrenal gland. Regulation and differential effects in fetal and adult cells.
Article in The Journal of clinical investigation, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 118 citations in OpenAlex.
- A challenging hypothesis: can a SNP changing cysteine 1 in the α inhibin pro-domain induce reproduction-linked PCOS phenotypes?Frontiers in endocrinology · 2026Review
- Inhibin A as a tumor marker for primary bilateral macronodular adrenal hyperplasia.Endocrinology, diabetes & metabolism case reports · 2020Article
- The transient cortical zone in the adrenal gland: the mystery of the adrenal X-zone.The Journal of endocrinology · 2019Review
- Bone Morphogenetic Protein-4 (BMP4): A Paracrine Regulator of Human Adrenal C19 Steroid Synthesis.Endocrinology · 2015Article
- A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-β1.Endocrinology · 2015Article
- Regulation of the adrenocortical stem cell niche: implications for disease.Nature reviews. Endocrinology · 2015Review
- Inhibin at 90: from discovery to clinical application, a historical review.Endocrine reviews · 2014Review
- Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice.Endocrinology · 2013Article
- Development and function of the human fetal adrenal cortex: a key component in the feto-placental unit.Endocrine reviews · 2011Review
- Activin A binds to perlecan through its pro-region that has heparin/heparan sulfate binding activity.The Journal of biological chemistry · 2010Article
- Cushing's syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice.PLoS genetics · 2010Article
- Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.Molecular and cellular biology · 2003Article
- Expression and localization of inhibin/activin and activin receptors in GH3 cells, a rat pituitary adenocarcinoma cell line.Journal of endocrinological investigation · 1996Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent experimental data have revealed that activins and inhibins exert pivotal effects on development. As part of our studies on growth and differentiation of the human fetal adrenal gland, we examined the subunit localization, as well as the mitogenic and steroidogenic actions of activin and inhibin in human fetal and adult adrenals. All three activin and inhibin subunit proteins (alpha, beta A, and beta B) were detected in the fetal and adult adrenal cortex. Immunoreactive activin-A dimer was demonstrated in midgestation fetal and neonatal adrenals. ACTH1-24-stimulated fetal adrenal cell expression of alpha and beta A subunit messenger RNA. In addition, ACTH elicited a rise in levels of immunoreactive alpha subunit secreted by fetal and adult adrenal cells. Human recombinant activin-A inhibited mitogenesis and enhanced ACTH-stimulated cortisol secretion by cultured fetal zone cells, but not definitive zone or adult adrenal cells. Recombinant inhibin-A had no apparent mitogenic or steroidogenic effects. Thus, activin selectively suppressed fetal zone proliferation and enhanced the ACTH-induced shift in the cortisol/dehydroepiandrosterone sulfate ratio of fetal zone steroid production. These data indicate that activin-A may be an autocrine or paracrine factor regulated by ACTH, involved in modulating growth and differentiated function of the human fetal adrenal gland.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.