ArticleThe Plant cell1992
A meristem-related gene from tomato encodes a dUTPase: analysis of expression in vegetative and floral meristems.
Article in The Plant cell, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Evaluation of critical design parameters for RT-qPCR-based analysis of multiple dUTPase isoform genes in mice.FEBS open bio · 2019Article
- Purification, crystallization and preliminary crystallographic analysis of deoxyuridine triphosphate nucleotidohydrolase from Arabidopsis thaliana.Acta crystallographica. Section F, Structural biology and crystallization communications · 2007Article
- Major proteome variations associated with cherry tomato pericarp development and ripening.Plant physiology · 2007Article
- Identification of genes specifically expressed in cauliflower reproductive meristems. Molecular characterization of BoREM1.Plant molecular biology · 1999Article
- Cloning and expression of the mouse deoxyuridine triphosphate nucleotidohydrolase gene: differs from the rat enzyme in that it lacks nuclear receptor interacting LXXLL motif.Gene expression · 1999Article
- Description of a novel eukaryotic deoxyuridine 5'-triphosphate nucleotidohydrolase in Leishmania major.The Biochemical journal · 1997Article
- dUTPase-minus caprine arthritis-encephalitis virus is attenuated for pathogenesis and accumulates G-to-A substitutions.Journal of virology · 1997Article
- The tef1 box, a ubiquitous cis-acting element involved in the activation of plant genes that are highly expressed in cycling cells.Molecular & general genetics : MGG · 1995Article
- Replication in vitro and in vivo of an equine infectious anemia virus mutant deficient in dUTPase activity.Journal of virology · 1995Article
- Article
- Isolation of a cytochrome P450 homologue preferentially expressed in developing inflorescences of Zea mays.Plant molecular biology · 1994Article
- Expression and purification of the mouse mammary tumor virus gag-pro transframe protein p30 and characterization of its dUTPase activity.Journal of virology · 1994Article
- Meristem-specific gene expression directed by the promoter of the S-phase-specific gene, cyc07, in transgenic Arabidopsis.Plant molecular biology · 1994Article
- Isolation of the tomato AGAMOUS gene TAG1 and analysis of its homeotic role in transgenic plants.The Plant cell · 1994Article
- The TM5 MADS Box Gene Mediates Organ Differentiation in the Three Inner Whorls of Tomato Flowers.The Plant cell · 1994Article
- dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae.The EMBO journal · 1993Article
- Determination and Cell Interactions in Reproductive Meristems.The Plant cell · 1993Article
- Gene Expression in the Early Floral Meristem.The Plant cell · 1993Article
- Modular organization and development activity of an Arabidopsis thaliana EF-1 alpha gene promoter.Molecular & general genetics : MGG · 1993Article
- The patterns of gene expression in the tomato shoot apical meristem.The Plant cell · 1993Article
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3 authors.
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Abstract
A meristem-specific gene coding for deoxyuridine triphosphatase (EC 3.6.1.23) (dUTPase) in tomato was isolated, and its developmental expression in vegetative and floral apices was monitored. An 18-kD polypeptide, P18, was isolated as a consequence of its accumulation in arrested floral meristems of anantha mutant plants. The corresponding cDNA isolated from an expression library exhibited a 40 to 60% similarity with the pseudoprotease sequences of poxviruses, genes that have been suggested to encode dUTPases. Enzymatic tests and conservation of peptide motifs common to bacterial and viral genes verified that the P18 cDNA clone indeed represents a eukaryotic dUTPase. Immunogold localization and in situ hybridization experiments showed that polypeptides and transcripts of dUTPase are maintained at high levels in apical meristematic cells of vegetative and floral meristems. dUTPase gene activity is also high in the potentially meristematic cells of the provascular and vascular system. Its expression is lower in the immediate parenchymal derivatives of the apical meristematic cells, and this downregulation marks, perhaps, the transition from totipotency to the first differentiated state.
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