ArticleProceedings of the National Academy of Sciences of the United States of America1992
Functional binding of the "TATA" box binding component of transcription factor TFIID to the -30 region of TATA-less promoters.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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58 citing papers in PubMed, 147 citations in OpenAlex.
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- TATA binding proteins can recognize nontraditional DNA sequences.Biophysical journal · 2012Article
- Differential transcription factor use by the KIR2DL4 promoter under constitutive and IL-2/15-treated conditions.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Protein-coding gene promoters in Methanocaldococcus (Methanococcus) jannaschii.Nucleic acids research · 2009Article
- Article
- The architecture of mammalian ribosomal protein promoters.BMC evolutionary biology · 2005Article
- Expression of nonclassical MHC class Ib genes: comparison of regulatory elements.Immunologic research · 2003Review
- Roles of an Ets motif and a novel CACGAC direct repeat in transcription of the murine dihydrolipoamide dehydrogenase (Dld) gene.The Biochemical journal · 1999Article
- Multiple domains for initiator binding proteins TFII-I and YY-1 are present in the initiator and upstream regions of the rat XDH/XO TATA-less promoter.Nucleic acids research · 1998Article
- Molecular cloning of a novel mouse gene with predominant muscle and neural expression.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- Transcription initiation from a poly(dA) tract.Nucleic acids research · 1998Article
- Differential regulation of the pre-C and pregenomic promoters of human hepatitis B virus by members of the nuclear receptor superfamily.Journal of virology · 1997Article
- Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1.The EMBO journal · 1997Article
- Identification of preferred hTBP DNA binding sites by the combinatorial method REPSA.Nucleic acids research · 1997Article
- Accurate positioning of RNA polymerase II on a natural TATA-less promoter is independent of TATA-binding-protein-associated factors and initiator-binding proteins.Molecular and cellular biology · 1997Article
- The major transcription initiation site of the SV40 late promoter is a potent thyroid hormone response element.Nucleic acids research · 1997Article
- The Epstein-Barr virus EBNA-1 promoter Qp requires an initiator-like element.Journal of virology · 1997Article
- Promoters for synthesis of the pre-C and pregenomic mRNAs of human hepatitis B virus are genetically distinct and differentially regulated.Journal of virology · 1996Article
- The NOT, SPT3, and MOT1 genes functionally interact to regulate transcription at core promoters.Molecular and cellular biology · 1996Article
- Interferon regulatory factors and TFIIB cooperatively regulate interferon-responsive promoter activity in vivo and in vitro.Molecular and cellular biology · 1996Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Many viral and cellular promoters transcribed in higher eukaryotes by RNA polymerase II lack obvious A+T-rich sequences, called "TATA" boxes, that bind the transcription factor TFIID. One such TATA-less promoter, the simian virus 40 major late promoter, contains a genetically important sequence element 30 base pairs upstream of its transcription initiation site that has no obvious sequence similarity to a TATA box. We show here that the cloned human TATA box-binding protein, hTFIID tau, functionally binds to this upstream sequence element, although with an affinity one-sixth of that to which it binds the TATA box of the adenovirus type 2 major late promoter. Analysis of point mutations in the -30 element of the simian virus 40 major late promoter shows that the affinity of binding correlates with the efficiency of transcription from this promoter. Furthermore, this element has genetic properties similar to those of a TATA box. (i) It directs RNA polymerase II to initiate transcription approximately 30 base pairs downstream of its location, and (ii) inactivation of this element results in increased heterogeneity in the sites of transcription initiation. All of five other TATA-less promoters tested were found to contain a sequence approximately 30 base pairs upstream of their major transcription initiation sites to which hTFIID tau binds. We conclude that many, if not all, TATA-less promoters differ from TATA box-containing promoters simply in the affinity of their -30 regions for binding of TFIID, with functional binding of TFIID supported in part by other nearby sequence elements of the promoter.
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