ArticleNature1992
Nuclear localization and signalling activity of phosphoinositidase C beta in Swiss 3T3 cells.
Article in Nature, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 324 citations in OpenAlex.
- Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle.JCI insight · 2018Trial
- Phosphoinositides and inositol phosphates as molecular glues.FEBS letters · 2026Review
- Phospholipase Cδ-4 (PLCδ4) Acts as a Nuclear Player to Influence Cyclin B Expression in the Embryonal Rhabdomyosarcoma Cell Lines RD and A204.Biomolecules · 2024Article
- Decoding how receptor tyrosine kinases (RTKs) mediate nuclear calcium signaling.Advances in biological regulation · 2024Review
- Review
- Nuclear Phosphoinositides as Key Determinants of Nuclear Functions.Biomolecules · 2023Review
- Phospholipase Family Enzymes in Lung Cancer: Looking for Novel Therapeutic Approaches.Cancers · 2023Review
- Review
- The basis of nuclear phospholipase C in cell proliferation.Advances in biological regulation · 2021Review
- Striking a balance: PIPExploration of neuroprotective therapy · 2021Article
- Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors.Cell chemical biology · 2020Article
- Phospholipase C.Advances in experimental medicine and biology · 2020Review
- Quantitative profiling of the endonuclear glycerophospholipidome of murine embryonic fibroblasts.Journal of lipid research · 2016Article
- Phospholipase C-η2 interacts with nuclear and cytoplasmic LIMK-1 during retinoic acid-stimulated neurite growth.Histochemistry and cell biology · 2016Article
- Article
- Regulation of phosphatidylinositol-specific phospholipase C at the nuclear envelope in cardiac myocytes.Journal of cardiovascular pharmacology · 2015Review
- A novel DAG-dependent mechanism links PKCɑ and Cyclin B1 regulating cell cycle progression.Oncotarget · 2014Article
- The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- An integrated mechanism of cardiomyocyte nuclear Ca(2+) signaling.Journal of molecular and cellular cardiology · 2014Review
- Role of phospholipase C-β in RNA interference.Advances in biological regulation · 2013Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdInsP2) is a widespread receptor-coupled signalling system at the plasma membrane of most eukaryotic cells. The existence of an entirely separate nuclear phosphoinositide signalling system is suggested from evidence that purified nuclei synthesize PtdInsP2 and phosphatidylinositol 4-phosphate (PtdInsP) in vitro and that a transient decrease in the mass of these lipids occurs when Swiss 3T3 cells are cultured in the presence of insulin-like growth factor-1 (IGF-1). These IGF-1-dependent changes in inositol lipids coincide with an increase in nuclear diacyglycerol and precede translocation to the nucleus and activation of protein kinase C (refs 5, 6). Circumstantial evidence that links these changes with mitosis comes from the isolation of a 3T3 clone that expresses the type-1 IGF receptor and binds IGF-1 peptide but does not respond mitogenically or show transient mass changes in nuclear inositol lipids. A key question is how IGF-1 initiates the rapid breakdown of PtdInsP and PtdInsP2 in the nucleus. Here we present evidence that nuclei of 3T3 cells contain the beta-isozyme of phosphoinositidase C, whereas the gamma-isozyme is confined to the cytoplasm and that IGF-1 treatment stimulates exclusively the activity of nuclear phosphoinositidase C.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.