ArticleMolecular and cellular biology1992
Murine helix-loop-helix transcriptional activator proteins binding to the E-box motif of the Akv murine leukemia virus enhancer identified by cDNA cloning.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Mutations in TCF12, encoding a basic helix-loop-helix partner of TWIST1, are a frequent cause of coronal craniosynostosis.Nature genetics · 2013Article
- HEB in the spotlight: Transcriptional regulation of T-cell specification, commitment, and developmental plasticity.Clinical & developmental immunology · 2012Review
- Suppression of chondrogenesis by Id helix-loop-helix proteins in murine embryonic orofacial tissue.Differentiation; research in biological diversity · 2009Article
- A murine leukemia virus with Cre-LoxP excisible coding sequences allowing superinfection, transgene delivery, and generation of host genomic deletions.Retrovirology · 2004Article
- Lack of shielding of primer binding site silencer-mediated repression of an internal promoter in a retrovirus vector by the putative insulators scs, BEAD-1, and HS4.Journal of virology · 2000Article
- A novel snail-related transcription factor Smuc regulates basic helix-loop-helix transcription factor activities via specific E-box motifs.Nucleic acids research · 2000Article
- The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms.Molecular and cellular biology · 2000Article
- A new class of plant homeobox genes is expressed in specific regions of determinate symbiotic root nodules.Plant molecular biology · 1999Article
- Members of the GATA family of transcription factors bind to the U3 region of Cas-Br-E and graffi retroviruses and transactivate their expression.Journal of virology · 1998Article
- Expression of a quail bHLH transcription factor is associated with adrenergic development in trunk neural crest cultures.Cellular and molecular neurobiology · 1997Article
- Interplay of the E box, the cyclic AMP response element, and HTF4/HEB in transcriptional regulation of the neurospecific, neurotrophin-inducible vgf gene.Molecular and cellular biology · 1997Article
- Second-site proviral enhancer alterations in lymphomas induced by enhancer mutants of SL3-3 murine leukemia virus: negative effect of nuclear factor 1 binding site.Journal of virology · 1997Article
- Various modes of basic helix-loop-helix protein-mediated regulation of murine leukemia virus transcription in lymphoid cell lines.Journal of virology · 1996Article
- E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein.Nucleic acids research · 1996Article
- ALF1, a basic helix-loop-helix transcription factor, maps to mouse chromosome 9.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Helix-loop-helix transcription factors mediate activation and repression of the p75LNGFR gene.Molecular and cellular biology · 1995Article
- A novel initiator regulates expression of the nontissue-specific helix-loop-helix gene ME1.Nucleic acids research · 1995Article
- Basic helix-loop-helix proteins in murine type C retrovirus transcriptional regulation.Journal of virology · 1994Article
- Pan/E2A expression precedes immunoglobulin heavy-chain expression during B lymphopoiesis in nontransformed cells, and Pan/E2A proteins are not detected in myeloid cells.Molecular and cellular biology · 1994Article
- Origins of enhancer sequences of recombinant murine leukemia viruses from spontaneous B- and T-cell lymphomas of CWD mice.Journal of virology · 1994Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The enhancer region of Akv murine leukemia virus contains the sequence motif ACAGATGG. This sequence is homologous to the E-box motif originally defined as a regulatory element in the enhancers of immunoglobulin mu and kappa genes. We have used double-stranded oligonucleotide probes, corresponding to the E box of the murine leukemia virus Akv, to screen a randomly primed lambda gt11 cDNA expression library made from mouse NIH 3T3 fibroblast RNA. We have identified seven lambda clones expressing DNA-binding proteins representing two different genes termed ALF1 and ALF2. The results of sequencing ALF2 cDNA suggests that we have recovered the gene for the basic-helix-loop-helix transcription factor A1, the murine analog of the human transcription factor E47. The cDNA sequence of ALF1 codes for a new member of the basic-helix-loop-helix protein family. Two splice variants of ALF1 cDNA have been found, differing by a 72-bp insertion, coding for putative proteins of 682 and 706 amino acids. The two ALF1 mRNAs are expressed at various levels in mouse tissues. In vitro DNA binding assays, using prokaryotically expressed ALF1 proteins, demonstrated specific binding of the ALF1 proteins to the Akv murine leukemia virus E-box motif ACAGATGG. Expression in NIH 3T3 fibroblasts of GAL4-ALF1 chimeric protein stimulated expression from a minimal promoter linked to a GAL4 binding site, indicating the existence of a transcriptional activator domain in ALF1.
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