ArticleThe EMBO journal1992
Role of associated gamma-chain in tyrosine kinase activation via murine Fc gamma RIII.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 83 citations in OpenAlex.
- Autonomous phagosomal degradation and antigen presentation in dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Syk-dependent actin dynamics regulate endocytic trafficking and processing of antigens internalized through the B-cell receptor.Molecular biology of the cell · 2007Article
- Diversity and duplicity: human FCgamma receptors in host defense and autoimmunity.Immunologic research · 2002Review
- Role of Fc gamma receptors in triggering host cell activation and cytokine release by Borrelia burgdorferi.Infection and immunity · 2001Article
- The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments.The Journal of cell biology · 2000Article
- Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization.The Journal of experimental medicine · 1999Article
- Syk tyrosine kinase and B cell antigen receptor (BCR) immunoglobulin-alpha subunit determine BCR-mediated major histocompatibility complex class II-restricted antigen presentation.The Journal of experimental medicine · 1998Article
- syk protein tyrosine kinase regulates Fc receptor gamma-chain-mediated transport to lysosomes.The EMBO journal · 1998Article
- Type II and III receptors for immunoglobulin G (IgG) control the presentation of different T cell epitopes from single IgG-complexed antigens.The Journal of experimental medicine · 1998Article
- A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing.The Journal of experimental medicine · 1997Article
- ITIMs and ITAMs. The Yin and Yang of antigen and Fc receptor-linked signaling machinery.Immunologic research · 1997Review
- Multisubunit receptors in the immune system and their association with the cytoskeleton: in search of functional significance.Immunologic research · 1995Review
- Different roles for the Fc epsilon RI gamma chain as a function of the receptor context.The Journal of experimental medicine · 1995Article
- Delineation of a T-cell activation motif required for binding of protein tyrosine kinases containing tandem SH2 domains.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- CD3+CD16+NK1.1+B220+ large granular lymphocytes arise from both alpha-beta TCR+CD4-CD8- and gamma-delta TCR+CD4-CD8- cells.The Journal of experimental medicine · 1994Article
- Functional expression in mast cells of chimeric receptors with antibody specificity.Cell biophysics · 1994Article
- Article
- Cross-linking of IgG receptors inhibits membrane immunoglobulin-stimulated calcium influx in B lymphocytes.The Journal of cell biology · 1993Article
- Cell surface control of the multiubiquitination and deubiquitination of high-affinity immunoglobulin E receptors.The EMBO journal · 1993Article
- Lineage-independent activation of immune system effector function by myeloid Fc receptors.The EMBO journal · 1992Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type III receptors for the Fc portion of IgG (Fc gamma RIII), initially characterized on macrophages and NK cells, are also expressed on several pre-B cell lines. Surface expression of Fc gamma RIII requires the association of the ligand binding alpha-chain with homodimeric gamma-chains. Type II Fc gamma R is homologous to Fc gamma RIII alpha-chain in the extracellular portion and differs in the transmembrane and cytoplasmic domains. The role of Fc gamma R in cell activation was investigated by expressing Fc gamma RIII and the lymphocyte-specific b1 isoform of Fc gamma RII (Fc gamma RIIb1) in an Fc gamma R-negative, sIgG-positive B-cell line. We found that, in contrast to Fc gamma RIIb1, Fc gamma RIII triggers the same events of cell activation as sIG i.e. Ca2+ mobilization, tyrosine phosphorylation and IL-2 secretion. By expressing cytoplasmic domain-lacking Fc gamma RIII alpha-chain in the absence or in the presence of gamma-chains, we demonstrated that cell activation via Fc gamma RIII requires the co-expression of gamma-chains, and is independent of the cytoplasmic portion of the alpha-chain. Furthermore, the cytoplasmic portion of the gamma-chain, fused to the extracellular and transmembrane domains of Fc gamma RII confers on the chimeric receptor the ability to trigger cell activation. Mutation of one tyrosine residue in the cytoplasmic domain of the gamma-chain prevented triggering of cytoplasmic signals. We therefore demonstrate that a tyrosine-containing motif, present in the cytoplasmic domain of the associated gamma-chain, is necessary and sufficient to trigger cell activation via Fc gamma RIII.
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