ArticleMolecular biology of the cell1992
Fission yeast sts1+ gene encodes a protein similar to the chicken lamin B receptor and is implicated in pleiotropic drug-sensitivity, divalent cation-sensitivity, and osmoregulation.
Article in Molecular biology of the cell, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 28 citations in OpenAlex.
- Elevated levels of sphingolipid MIPC in the plasma membrane disrupt the coordination of cell growth with cell wall formation in fission yeast.PLoS genetics · 2023Article
- Two novel genes induced by hard-surface contact of Colletotrichum gloeosporioides conidia.Journal of bacteriology · 2000Article
- PCR-mediated direct gene disruption in Schizosaccharomyces pombe.Nucleic acids research · 1997Article
- Caffeine-resistance in fission yeast is caused by mutations in a single essential gene, crm1+.Molecular & general genetics : MGG · 1996Article
- Phylogenesis of fission yeasts. Contradictions surrounding the origin of a century old genus.Antonie van Leeuwenhoek · 1995Review
- Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review.Lipids · 1995Review
- Colocalization of vertebrate lamin B and lamin B receptor (LBR) in nuclear envelopes and in LBR-induced membrane stacks of the yeast Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Type B lamins remain associated with the integral nuclear envelope protein p58 during mitosis: implications for nuclear reassembly.The EMBO journal · 1994Article
- Genetic interactions among genes involved in the STT4-PKC1 pathway of Saccharomyces cerevisiae.Molecular & general genetics : MGG · 1994Article
- Two novel protein kinase C-related genes of fission yeast are essential for cell viability and implicated in cell shape control.The EMBO journal · 1993Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1992Article
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4 authors at 1 institution in 1 country.
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Abstract
The Schizosaccharomyces pombe sts1+ gene, identified by supersensitive mutations to a protein kinase inhibitor, staurosporine, was isolated by complementation by the use of a fission yeast genomic library. Nucleotide sequencing shows that the sts1+ gene encodes a 453 amino acid putative membrane-associated protein that is significantly similar (26% identity) to the chicken lamin B receptor. It is also highly related (53% identity) to a budding yeast ORF, YGL022. These three proteins contain a similar hydrophobicity pattern consisting of eight or nine putative transmembrane domains. By gene disruption we demonstrate that the sts1+ gene is not essential for viability. These disruptants exhibit pleiotropic defects, such as cold-sensitivity for growth and at the permissive temperature, a supersensitivity to divalent cations and several unrelated drugs including staurosporine, caffeine, chloramphenicol, sorbitol, and SDS. Disruption of the sts1+ gene does not lead to a sensitivity to thiabendazole or hydroxyurea.
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