ArticleJournal of molecular neuroscience : MN1992
Continuous culture of neuronal cells from adult human olfactory epithelium.
Article in Journal of molecular neuroscience : MN, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 70 citations in OpenAlex.
- Olfactory models as a platform for neuroscience research.Frontiers in cellular neuroscience · 2026Review
- Strategies to Develop Regenerative Medicine Approaches for Olfactory Disorders.Clinical and experimental otorhinolaryngology · 2025Review
- Cultured Mesenchymal Cells from Nasal Turbinate as a Cellular Model of the Neurodevelopmental Component of Schizophrenia Etiology.International journal of molecular sciences · 2023Article
- Cultured Mesenchymal Cells from Nasal Turbinate as a Cellular Model of the Neurodevelopmental Component of Schizophrenia Etiology.bioRxiv : the preprint server for biology · 2023Article
- Primary Culture of the Human Olfactory Neuroepithelium and Utilization for Henipavirus Infection In Vitro.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Analyzing Olfactory Neuron Precursors Non-Invasively Isolated through NADH FLIM as a Potential Tool to Study Oxidative Stress in Alzheimer's Disease.International journal of molecular sciences · 2021Review
- Olfactory Neuroepithelium Cells from Cannabis Users Display Alterations to the Cytoskeleton and to Markers of Adhesion, Proliferation and Apoptosis.Molecular neurobiology · 2021Article
- Bilateral Olfactory Mucosa Damage Induces the Disappearance of Olfactory Glomerulus and Reduces the Expression of Extrasynaptic α5GABANeurotoxicity research · 2018Article
- Translational potential of olfactory mucosa for the study of neuropsychiatric illness.Translational psychiatry · 2015Review
- Isolation and culture of human fungiform taste papillae cells.Journal of visualized experiments : JoVE · 2012Article
- Olfactory stem cells, a new cellular model for studying molecular mechanisms underlying familial dysautonomia.PloS one · 2010Article
- Human olfactory epithelial cells generated in vitro express diverse neuronal characteristics.Neuroscience · 2009Article
- Reconstructing smell.Molecular neurobiology · 2000Review
- Isolation and in vitro differentiation of conditionally immortalized murine olfactory receptor neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Alzheimer and beta-amyloid-treated fibroblasts demonstrate a decrease in a memory-associated GTP-binding protein, Cp20.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Long-term culture and functional characterization of follicular cells from adult normal human thyroids.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Regulation of olfactory neuron gene expression.Cytotechnology · 1993Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells from the olfactory epithelium of adult human cadavers have been propagated in primary culture and subsequently cloned. These cells exhibit neuronal properties including: neuron-specific enolase, olfactory marker protein, neurofilaments, and growth-associated protein 43. Simultaneously, the cells exhibit nonneuronal properties such as glial fibrillary acidic protein and keratin, the latter suggesting properties of neuroblasts or stem cells. These clonal cultures contain 5-10% of cells sufficiently differentiated to show odorant-dependent cyclic adenosine 3',5'-monophosphate (cAMP) or calcium-release responses when challenged with submicromolar concentrations of odorants. The potential of culturing neuronal cells from patients with neuropsychiatric disorders, such as Alzheimer's disease or schizophrenia, could enable the study of the pathophysiology of these neurons in the culture dish and allow new approaches to the study of mental illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.