ArticlePflugers Archiv : European journal of physiology1992
Interleukin-2 inhibits sodium currents in human muscle cells.
Article in Pflugers Archiv : European journal of physiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 29 citations in OpenAlex.
- Rapid protein kinase C-dependent reduction of rat skeletal muscle voltage-gated sodium channels by ciliary neurotrophic factor.The Journal of physiology · 2005Article
- The pathophysiology of multiple sclerosis: the mechanisms underlying the production of symptoms and the natural history of the disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1999Review
- Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis.Nature medicine · 1998Article
- Serine-1321-independent regulation of the mu 1 adult skeletal muscle Na+ channel by protein kinase C.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Local anaesthetic-like effect of interleukin-2 on muscular Na+ channels: no evidence for involvement of the IL-2 receptor.Pflugers Archiv : European journal of physiology · 1994Article
- Interleukin-2 inhibits sodium currents in human muscle cells.Pflugers Archiv : European journal of physiology · 1992Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of the T cell growth factor interleukin-2 (IL-2) on muscular Na+ channels was studied in myoballs produced from primary human muscle cultures. The transient Na+ inward currents of the myoballs, elicited by repetitive stimulation at 1 Hz and recorded in the whole-cell mode, were inhibited by IL-2 applied to the external solution, the half maximum effect occurring at 300 U/ml. The effect was complete within 5 s and was totally reversible, the on and off effects having identical time courses. The h infinity curve was shifted in negative direction indicating that the mechanism of IL-2 action is a conversion of the Na+ channels into a state of inactivation. The reaction of the IL-2 solution with an anti IL-2 antibody neutralized the inhibitory effect on the Na+ currents, indicating a specific effect of the peptide growth factor interleukin-2 on muscular Na+ channels. The connection of IL-2 and Na+ channels may be important in inflammatory processes of muscle and nerve.
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