ArticleMolecular biology of the cell1992
The beta-PDGF receptor induces neuronal differentiation of PC12 cells.
Article in Molecular biology of the cell, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 145 citations in OpenAlex.
- Emerging roles of transcriptional condensates as temporal signal integrators.Nature reviews. Genetics · 2025Review
- Optogenetic control of YAP reveals a dynamic communication code for stem cell fate and proliferation.Nature communications · 2023Article
- Tyrphostin A9 protects axons in experimental autoimmune encephalomyelitis through activation of ERKs.Life sciences · 2022Article
- Feedback activation of neurofibromin terminates growth factor-induced Ras activation.Cell communication and signaling : CCS · 2016Article
- Light-mediated kinetic control reveals the temporal effect of the Raf/MEK/ERK pathway in PC12 cell neurite outgrowth.PloS one · 2014Article
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- AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.Chemistry & biology · 2011Article
- Feedback regulation of EGFR signalling: decision making by early and delayed loops.Nature reviews. Molecular cell biology · 2011Review
- Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice.Seminars in immunology · 2010Review
- Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cells.The Journal of biological chemistry · 2010Article
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- FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development.Neural development · 2008Article
- Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation.The EMBO journal · 2007Article
- Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival.Molecular biology of the cell · 2007Article
- Domain-dependent modulation of PDGFRbeta by ganglioside GM1.Journal of molecular neuroscience : MN · 2003Article
- Lysophospholipid receptors in the nervous system.Neurochemical research · 2002Review
- P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Neural cell adhesion molecule-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-mitogen-activated protein kinase pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation.Molecular and cellular biology · 1999Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Expression of the mouse beta-PDGF receptor by gene transfer confers PDGF-dependent and reversible neuronal differentiation of PC12 pheochromocytoma cells similar to that observed in response to NGF and basic FGF. A common property of the PDGF, NGF, and basic FGF-induced differentiation response is the requirement for constant exposure of cells to the growth factor. To test the hypothesis that a persistent level of growth factor receptor signaling is required for the maintenance of the neuronal phenotype, we examined the regulation of the serine/threonine-specific MAP kinases after either short- (10 min) or long-term (24 h) stimulation with growth factors. Mono Q FPLC resolved two peaks of growth factor-stimulated MAP kinase activity that coeluted with tyrosine phosphorylated 41- and 43-kDa polypeptides. MAP kinase activity was markedly stimulated (approximately 30-fold) within 5 min of exposure to several growth factors (PDGF, NGF, basic FGF, EGF, and IGF-I), but was persistently maintained at 10-fold above basal activity after 24 h only by the growth factors that also induce PC12 cell differentiation (PDGF, NGF, and basic FGF). Thus the beta-PDGF receptor is in a subset of tyrosine kinase-encoded growth factor receptors that are capable of maintaining continuous signals required for differentiation of PC12 cells. These signals include the constitutive activation of cytoplasmic serine/threonine protein kinases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.