ArticleProceedings of the National Academy of Sciences of the United States of America1992
Human cytomegalovirus origin of DNA replication (oriLyt) resides within a highly complex repetitive region.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 90 citations in OpenAlex.
- Human cytomegalovirus long non-coding RNA counteracts nuclear cGAS to facilitate immune evasion.Nature microbiology · 2025Article
- Cytomegalovirus Genetic Diversity and Evolution: Insights into Genotypes and Their Role in Viral Pathogenesis.Pathogens (Basel, Switzerland) · 2025Review
- Functional and molecular dissection of HCMV long non-coding RNAs.Scientific reports · 2022Article
- The human cytomegalovirus decathlon: Ten critical replication events provide opportunities for restriction.Frontiers in cell and developmental biology · 2022Review
- Article
- Characteristics of Immediate-Early 2 (IE2) and UL84 Proteins in UL84-Independent Strains of Human Cytomegalovirus (HCMV).Microbiology spectrum · 2021Article
- Human cytomegalovirus long noncoding RNA4.9 regulates viral DNA replication.PLoS pathogens · 2020Article
- Human Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic Legion.Pathogens (Basel, Switzerland) · 2019Review
- pUL34 binding near the human cytomegalovirus origin of lytic replication enhances DNA replication and viral growth.Virology · 2018Article
- Enrichment by hybridisation of long DNA fragments for Nanopore sequencing.Microbial genomics · 2016Article
- Human cytomegalovirus UL34 binds to multiple sites within the viral genome.Journal of virology · 2013Article
- A novel bat herpesvirus encodes homologues of major histocompatibility complex classes I and II, C-type lectin, and a unique family of immune-related genes.Journal of virology · 2012Article
- Cytomegalovirus replicon-based regulation of gene expression in vitro and in vivo.PLoS pathogens · 2012Article
- Host-viral effects of chromatin assembly factor 1 interaction with HCMV IE2.Cell research · 2011Article
- Importance sampling of word patterns in DNA and protein sequences.Journal of computational biology : a journal of computational molecular cell biology · 2010Article
- Nucleocytoplasmic shuttling of human cytomegalovirus UL84 is essential for virus growth.Journal of virology · 2010Article
- Least-Squares Support Vector Machine Approach to Viral Replication Origin Prediction.INFORMS journal on computing · 2010Article
- Initiation of lytic DNA replication in Epstein-Barr virus: search for a common family mechanism.Future virology · 2010Article
- Interaction of HCMV UL84 with C/EBPalpha transcription factor binding sites within oriLyt is essential for lytic DNA replication.Virology · 2009Article
- Human cytomegalovirus UL84 interacts with an RNA stem-loop sequence found within the RNA/DNA hybrid region of oriLyt.Journal of virology · 2007Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A global analysis of the 230-kilobase-pair (kbp) human cytomegalovirus genome revealed three regions that were very rich in repeated sequences. The region with the highest content of inverted and direct repeats lies between 92,100 and 93,500 bp, upstream of the gene encoding the single-stranded DNA binding protein. Cloned restriction fragments containing this region were able to replicate when trans-acting factors were provided by virus infection in a transient replication assay. With this assay, the region between 92,210 and 93,715 bp on the viral genome was defined as the minimal replication origin, oriLyt. The sequence composition and repeats within oriLyt were used to divide the region into two domains that may be important in origin function. Sequences flanking either the left or right side of the minimal oriLyt contributed to efficient replication; however, these sequences were not essential for origin function. Thus, the region of the viral genome with the most striking concentration of direct and inverted repeats corresponds to the oriLyt of human cytomegalovirus.
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