ArticleAntimicrobial agents and chemotherapy1992
Cytotoxicity of acridine compounds for Leishmania promastigotes in vitro.
Article in Antimicrobial agents and chemotherapy, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Synthesis, Biological Evaluation, Molecular Dynamics, and QM-MM Calculation of Spiro-Acridine Derivatives Against Leishmaniasis.Microorganisms · 2025Article
- Evolution of Acridines and Xanthenes as a Core Structure for the Development of Antileishmanial Agents.Pharmaceuticals (Basel, Switzerland) · 2022Review
- New Approaches to Overcome Transport Related Drug Resistance in Trypanosomatid Parasites.Frontiers in pharmacology · 2016Review
- Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery.International journal for parasitology. Drugs and drug resistance · 2014Review
- Development of an ex vivo lymph node explant model for identification of novel molecules active against Leishmania major.Antimicrobial agents and chemotherapy · 2014Article
- Novel anti-Cryptosporidium activity of known drugs identified by high-throughput screening against parasite fatty acyl-CoA binding protein (ACBP).The Journal of antimicrobial chemotherapy · 2012Article
- Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers.Cell communication and signaling : CCS · 2011Article
- Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.Antimicrobial agents and chemotherapy · 2007Article
- The efficacy of enrofloxacin, alone or combined with metronidazole, in the therapy of canine leishmaniasis.Parasitology research · 2004Article
- In vitro activities of 7-substituted 9-chloro and 9-amino-2-methoxyacridines and their bis- and tetra-acridine complexes against Leishmania infantum.Antimicrobial agents and chemotherapy · 2003Article
- Effect of structure on antibiotic action of new 9-(ethylthio)acridines.Folia microbiologica · 2002Article
- Activity and mode of action of acridine compounds against Leishmania donovani.Antimicrobial agents and chemotherapy · 1996Article
- Effect of mitonafide analogs on topoisomerase II of Leishmania chagasi.Antimicrobial agents and chemotherapy · 1996Article
- 9-Anilinoacridines as potential antileishmanial agents.Antimicrobial agents and chemotherapy · 1993Article
- In vitro study of anticancer acridines as potential antitrypanosomal and antimalarial agents.Antimicrobial agents and chemotherapy · 1992Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The effect of mammalian and bacterial topoisomerase II inhibitors on Leishmania promastigotes was studied in vitro. Parasites were incubated with drugs, and cytotoxicity was assessed on the basis of the loss of flagellar motility and cell lysis after 48 h. 9-Aminoacridines, which are structurally related to the known antileishmanial compounds quinacrine and chlorpromazine, showed activity against the parasite at concentrations in the range of 10 to 20 microM. Adriamycin showed far less activity, while etoposide and several quinolones were inactive at 100-microM concentrations. These results demonstrate that a particular structural class of compounds is cytotoxic to Leishmania species. The unique structure-activity relationship discovered suggests that leishmanial topoisomerase II could be a useful target for chemotherapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.