ArticlePflugers Archiv : European journal of physiology1992
An analysis of Na+ currents in rat olfactory receptor neurons.
Article in Pflugers Archiv : European journal of physiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- NaV1.5 sodium channel window currents contribute to spontaneous firing in olfactory sensory neurons.Journal of neurophysiology · 2014Article
- Mechanisms underlying odorant-induced and spontaneous calcium signals in olfactory receptor neurons of spiny lobsters, Panulirus argus.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2014Article
- The Na(V)1.7 sodium channel: from molecule to man.Nature reviews. Neuroscience · 2013Review
- Nav1.7 is the predominant sodium channel in rodent olfactory sensory neurons.Molecular pain · 2011Article
- Chemical structures of odorants that suppress ion channels in the olfactory receptor cell.The journal of physiological sciences : JPS · 2011Article
- Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin-releasing hormone (GnRH) neurons.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Modulation of spontaneous and odorant-evoked activity of rat olfactory sensory neurons by two anorectic peptides, insulin and leptin.Journal of neurophysiology · 2009Article
- An estimate of the resting membrane resistance of frog olfactory receptor neurones.The Journal of physiology · 2004Article
- Dynamic activation of K(ATP) channels in rhythmically active neurons.The Journal of physiology · 2001Article
- A depolarizing chloride current contributes to chemoelectrical transduction in olfactory sensory neurons in situ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Odorant-induced currents in intact patches from rat olfactory receptor neurons: theory and experiment.Biophysical journal · 1997Article
- Nonselective suppression of voltage-gated currents by odorants in the newt olfactory receptor cells.The Journal of general physiology · 1997Article
- Electrophysiological characterization of chemosensory neurons from the mouse vomeronasal organ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Guanine nucleotides modulate steady-state inactivation of voltage-gated sodium channels in frog olfactory receptor neurons.The Journal of membrane biology · 1994Article
- Action potentials and chemosensitive conductances in the dendrites of olfactory neurons suggest new features for odor transduction.The Journal of general physiology · 1994Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Na+ currents were observed in acutely-dissociated adult rat olfactory receptor neurons using the whole-cell recording techniques. The threshold for current activation was near -70 mV and currents were fully activated by -10 mV (midpoint: -45 mV). Steady-state inactivation was complete at potentials more positive than -70 mV and half complete at -110 mV (+/- less than 1, n = 8). Complete recovery from inactivation required one second at -100 mV (n = 7). The addition of 10 microM tetrodotoxin or 1 mM Zn2+ to the external solution was required to completely block the current. The current differs from those in amphibian and cultured neonatal rat olfactory neurons in its unusually negative voltage-dependence and slow recovery. Since mammalian olfactory neurons have very high input resistances, physiological resting potentials cannot usually be measured using whole-cell recording techniques. However, predominantly-capacitatively-coupled spikes activated by depolarisation were frequently observed in cell-attached patches. This indicates that the cells were excitable and implies that they must have had resting potentials more negative than -90 mV in order for this current to underlie the action potential.
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Registered trials
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