ArticleThe Journal of general physiology1992
Aminoglycoside antibiotics block voltage-dependent calcium channels in intact vertebrate nerve terminals.
Article in The Journal of general physiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Aminoglycoside use and intensive care unit-acquired weakness: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Review
- Calcium channel inhibitor and extracellular calcium improve aminoglycoside-induced hair cell loss in zebrafish.Archives of toxicology · 2024Article
- The effect of high concentration of magnesium with ropivacaine, gentamicin, rocuronium, and their combination on neuromuscular blockade.Korean journal of anesthesiology · 2015Article
- Gentamicin blocks the ACh-induced BK current in guinea pig type II vestibular hair cells by competing with Ca²⁺ at the L-type calcium channel.International journal of molecular sciences · 2014Article
- Do bupivacaine, clindamycin, and gentamicin at their clinical concentrations enhance rocuronium-induced neuromuscular block?Korean journal of anesthesiology · 2013Article
- Gentamicin Reduces Calcific Nodule Formation by Aortic Valve Interstitial CellsCardiovascular engineering and technology · 2013Article
- Adverse effects of antimicrobials via predictable or idiosyncratic inhibition of host mitochondrial components.Antimicrobial agents and chemotherapy · 2012Review
- Aminoglycoside antibiotics: structure, functions and effects on in vitro plant culture and genetic transformation protocols.Plant cell reports · 2010Review
- Long-lasting intrinsic optical changes observed in the neurointermediate lobe of the mouse pituitary reflect volume changes in cells of the pars intermedia.Neuroendocrinology · 2010Article
- Pathways of abnormal stress-induced Ca2+ influx into dystrophic mdx cardiomyocytes.Cell calcium · 2009Article
- Effects of medial olivocochlear efferent stimulation on the activity of neurons in the auditory midbrain.Experimental brain research · 2008Article
- Calcium and neostigmine antagonize gentamicin, but augment clindamycin-induced tetanic fade in rat phrenic nerve-hemidiaphragm preparations.Journal of anesthesia · 2008Article
- A mechanical spike accompanies the action potential in Mammalian nerve terminals.Biophysical journal · 2007Article
- Properties of new, long-wavelength, voltage-sensitive dyes in the heart.The Journal of membrane biology · 2005Article
- Changes in FAD and NADH fluorescence in neurosecretory terminals are triggered by calcium entry and by ADP production.The Journal of membrane biology · 2005Article
- Gentamicin blocks ACh-evoked K+ current in guinea-pig outer hair cells by impairing Ca2+ entry at the cholinergic receptor.The Journal of physiology · 2000Article
- Micromolar 4-aminopyridine enhances invasion of a vertebrate neurosecretory terminal arborization: optical recording of action potential propagation using an ultrafast photodiode-MOSFET camera and a photodiode array.The Journal of general physiology · 1996Article
- Elimination of peripheral auditory pathway activation does not affect motor responses from ultrasound neuromodulation.Brain stimulationArticle
- Calcium-sensing receptor: a high-affinity presynaptic target for aminoglycoside-induced weakness.NeuropharmacologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Intrinsic and extrinsic optical signals recorded from the intact nerve terminals of vertebrate neurohypophyses were used to investigate the anatomical site and physiological mechanism of the antagonistic effects of aminoglycoside antibiotics on neurotransmission. Aminoglycoside antibiotics blocked the intrinsic light scattering signal closely associated with neurosecretion in the mouse neurohypophysis in a concentration-dependent manner with an IC50 of approximately 60 microM and the block was relieved by increasing [Ca2+]o. The rank order potency of different aminoglycoside antibiotics for blocking neurosecretion in this preparation was determined to be: neomycin greater than gentamicin = kanamycin greater than streptomycin. Optical recordings of rapid changes in membrane potential using voltage-sensitive dyes revealed that aminoglycoside antibiotics decreased the Ca(2+)-dependent after-hyperpolarization of the normal action potential and both the magnitude and after-hyperpolarization of the regenerative Ca2+ spike. The after-hyperpolarization results from a Ca-activated potassium conductance whose block by aminoglycoside antibiotics was also reversed by increased [Ca2+]o. These studies demonstrate that the capacity of aminoglycoside antibiotics to antagonize neurotransmission can be attributed to the block of Ca channels in the nerve terminal.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.