ArticleProceedings of the National Academy of Sciences of the United States of America1992
Immortal rat hippocampal cell lines exhibit neuronal and glial lineages and neurotrophin gene expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed.
- Mechanism of Molecular Activity of Yolkin-a Polypeptide Complex Derived from Hen Egg Yolk-in PC12 Cells and Immortalized Hippocampal Precursor Cells H19-7.Molecular neurobiology · 2023Article
- Article
- Early Developmental PMCA2b Expression Protects From Ketamine-Induced Apoptosis and GABA Impairments in Differentiating Hippocampal Progenitor Cells.Frontiers in cellular neuroscience · 2022Article
- The Potential Use of Sialic Acid From Edible Bird's Nest to Attenuate Mitochondrial Dysfunction byFrontiers in pharmacology · 2021Article
- Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer's Disease.Molecules (Basel, Switzerland) · 2019Review
- Late Maternal Folate Supplementation Rescues from Methyl Donor Deficiency-Associated Brain Defects by Restoring Let-7 and miR-34 Pathways.Molecular neurobiology · 2017Article
- Early methyl donor deficiency may induce persistent brain defects by reducing Stat3 signaling targeted by miR-124.Cell death & disease · 2013Article
- RKIP regulates MAP kinase signaling in cells with defective B-Raf activity.Cellular signalling · 2013Article
- Immortalization of neuronal progenitors using SV40 large T antigen and differentiation towards dopaminergic neurons.Journal of cellular and molecular medicine · 2012Review
- Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Induction of the GABA cell phenotype: an in vitro model for studying neurodevelopmental disorders.PloS one · 2012Article
- Freud-2/CC2D1B mediates dual repression of the serotonin-1A receptor gene.The European journal of neuroscience · 2011Article
- Total synthesis of (+)-nankakurines A and B and (±)-5-epi-nankakurine A.The Journal of organic chemistry · 2010Article
- Neuroprotection signaling pathway of nerve growth factor and brain-derived neurotrophic factor against staurosporine induced apoptosis in hippocampal H19-7/IGF-IR [corrected].Experimental & molecular medicine · 2010Article
- Raf kinase inhibitory protein function is regulated via a flexible pocket and novel phosphorylation-dependent mechanism.Molecular and cellular biology · 2009Article
- Nicotine inhibits bFGF-induced neurite outgrowth through suppression of NO synthesis in H19-7 cells.Neurochemical research · 2007Article
- Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling.Oncogene · 2006Article
- Protein synthesis required for long-term memory is induced by PKC activation on days before associative learning.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Establishment and characterization of an immortalized Z310 choroidal epithelial cell line from murine choroid plexus.Brain research · 2002Article
- The role of the insulin receptor substrate-1 in the differentiation of rat hippocampal neuronal cells.Oncogene · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Clonal cell lines of rat embryonic hippocampal origin have been developed by using retroviral transduction of temperature-sensitive simian virus 40 large tumor antigens. The cell lines undergo morphological differentiation at the nonpermissive temperature and in response to differentiating agents. Immunocytochemical analysis indicates that various lines are derived from progenitors of neuronal, glial, and bipotential lineages. Selected neuronal lines differentiate in response to diffusible factors released by primary glia, and one line of glial lineage supports the maturation of primary neurons in culture. Selected cell lines exhibit different patterns of neurotrophin gene expression that change after differentiation. In some lines, the relative levels of neurotrophin 3 and brain-derived neurotrophic factor message expression may reflect the developmental or regional differential expression seen for these genes in the hippocampus in situ. These hippocampal cell lines, which express markers indicative of commitment to neuronal or glial lineages, are valuable for studies of development and plasticity in these lineages, as well as for studies of the regulation of neural trophic interactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.