ArticleJournal of virology1992
Enhancer dependence of polyomavirus persistence in mouse kidneys.
Article in Journal of virology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Polyomavirus Wakes Up and Chooses Neurovirulence.Viruses · 2023Review
- Ischemia-Reperfusion Injury and Immunosuppressants Promote Polyomavirus Replication Through Common Molecular Mechanisms.Frontiers in immunology · 2022Article
- SV40 lymphomagenesis in Syrian golden hamsters.Virology · 2009Article
- Influence of the viral regulatory region on tumor induction by simian virus 40 in hamsters.Journal of virology · 2008Article
- Receptor-binding and oncogenic properties of polyoma viruses isolated from feral mice.PLoS pathogens · 2007Article
- Article
- Stimulation of DNA replication from the polyomavirus origin by PCAF and GCN5 acetyltransferases: acetylation of large T antigen.Molecular and cellular biology · 2002Article
- Systemic polyomavirus genome increase and dissemination of capsid-defective genomes in mammary gland tumor-bearing mice.Journal of virology · 2000Article
- Discrimination between sialic acid-containing receptors and pseudoreceptors regulates polyomavirus spread in the mouse.Journal of virology · 1999Article
- Oncogenesis of mammary glands, skin, and bones by polyomavirus correlates with viral persistence and prolonged genome replication potential.Journal of virology · 1997Article
- An enhancer of recombination in polyomavirus DNA.Journal of virology · 1996Article
- Genetic and structural analysis of a virulence determinant in polyomavirus VP1.Journal of virology · 1995Article
- The evolution of small DNA viruses of eukaryotes: past and present considerations.Virus genes · 1995Review
- n-Butyrate, a cell cycle blocker, inhibits the replication of polyomaviruses and papillomaviruses but not that of adenoviruses and herpesviruses.Journal of virology · 1994Article
- Aphidicolin-resistant polyomavirus and subgenomic cellular DNA synthesis occur early in the differentiation of cultured myoblasts to myotubes.Journal of virology · 1993Article
- Coevolution of persistently infecting small DNA viruses and their hosts linked to host-interactive regulatory domains.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Adult mouse kidneys become permissive to acute polyomavirus infection and reactivate persistent infections in response to cellular damage and regeneration.Journal of virology · 1993Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We previously showed that alterations in the enhancer sequence of polyomavirus DNA can alter both the level and the organ specificity of viral DNA replication during the acute phase of infection of newborn mice (R. Rochford, B. A. Campbell, and L. P. Villarreal, J. Virol. 64:476-485, 1990). In this study, we examined whether these enhancer sequence alterations can also affect polyomavirus replication during the persistent phase of infection in vivo. After infection of newborn mice with a mixture of three enhancer variants, the individual organs could select for enhancer-specific viral DNA replication during both the acute and the persistent phases of infection. Contrary to expectations, the ability of some variants to establish a high-level acute infection in some organs (e.g., the pancreas) did not necessarily lead to a persistent infection in those organs. Thus, enhancers can affect acute and persistent infections differently. In addition, some enhancer variants tended to establish a high-level persistent infection in the kidneys immediately following an acute infection; however, in all cases considerable histopathology was associated with these elevated long-term infections, and these mice were always runty. A persistent infection in the kidneys thus appears able to exist in two distinguishable states, a high-level pathological state and a low-level nonpathological state, which can be affected by the viral enhancer sequence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.