ArticleThe Journal of allergy and clinical immunology1992
Rhinovirus 39 infection in allergic and nonallergic subjects.
Article in The Journal of allergy and clinical immunology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 66 citations in OpenAlex.
- The role of virus in nasal inflammation.European journal of medical research · 2025Review
- Optimism as a key factor in coping with the common cold.Brain, behavior, & immunity - health · 2024Article
- The Role of Environmental Risk Factors on the Development of Childhood Allergic Rhinitis.Children (Basel, Switzerland) · 2021Review
- Are respiratory viruses involved in preseasonal symptoms or severity in Japanese cedar pollinosis?Allergy & rhinology (Providence, R.I.) · 2016Article
- Changes in microbiota during experimental human Rhinovirus infection.BMC infectious diseases · 2015Article
- Eustachian tube opening measured by sonotubometry is poorer in adults with a history of past middle ear disease.International journal of pediatric otorhinolaryngology · 2014Article
- Response to infections in patients with asthma and atopic disease: an epiphenomenon or reflection of host susceptibility?The Journal of allergy and clinical immunology · 2012Review
- The interleukin 6 -174 C/C genotype predicts greater rhinovirus illness.The Journal of infectious diseases · 2010Article
- Rhinovirus disrupts the barrier function of polarized airway epithelial cells.American journal of respiratory and critical care medicine · 2008Article
- Viral respiratory infection and the link to asthma.The Pediatric infectious disease journal · 2008Article
- Viral infections and susceptibility to recurrent sinusitis.Current allergy and asthma reports · 2005Review
- Article
- Mechanism of rhinovirus-induced changes in airway smooth muscle responsiveness.The Journal of clinical investigation · 1998Article
- [Acute viral respiratory tract infections and childhood asthma].Revue francaise d'allergologie et d'immunologie clinique · 1996Review
- Bronchial inflammation and the common cold: a comparison of atopic and non-atopic individuals.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 1996Article
- Effect of experimental influenza A virus infection on isolation of Streptococcus pneumoniae and other aerobic bacteria from the oropharynges of allergic and nonallergic adult subjects.Infection and immunity · 1995Article
- Complete sequence of the RNA genome of human rhinovirus 16, a clinically useful common cold virus belonging to the ICAM-1 receptor group.Virus genes · 1995Article
- Amplified rhinovirus colds in atopic subjects.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 1994Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
To determine if individuals with allergic rhinitis are hyperresponsive to upper respiratory tract viral infections, 20 allergic and 18 nonallergic, susceptible, adult volunteers were challenged and infected with rhinovirus type 39 before the pollen seasons. Before challenge and on each of 6 days of cloister, all volunteers were interviewed for symptoms and completed a test battery consisting of evaluations of secretion production by weighed tissues, nasal patency by active posterior rhinomanometry, nasal clearance by the dyed saccharin technique, pulmonary function by spirometry, eustachian tube function by sonotubometry, and middle ear status by tympanometry. The symptomatology and pathophysiology resulting from the rhinovirus infection were consistent with those reported in previous studies with this challenge system. Between-group comparisons revealed no differences in symptom presentation, nasal secretion production, or overall pathophysiologic response. However, for decreased mucociliary clearance rate, increased nasal congestion, eustachian tube dysfunction, and symptoms of sneezing, the allergic group demonstrated an earlier onset compared with that of the nonallergic group. The biologic significance of the differences in onset of dysfunction is tempered by the observation that the temporal pattern of responses in the allergic group was similar with that of nonallergic subjects in previous studies. The results of the present study do not support the hypothesis of a physiologic hyperresponsiveness to rhinovirus type 39 infection in allergic subjects during nonallergy seasons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.