ArticleThe EMBO journal1992
A confined variable region confers ligand specificity on fibroblast growth factor receptors: implications for the origin of the immunoglobulin fold.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 163 citations in OpenAlex.
- The Complexity and Significance of Fibroblast Growth Factor (FGF) Signaling for FGF-Targeted Cancer Therapies.Cancers · 2024Review
- Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling.Cells · 2021Review
- FGFR4: A promising therapeutic target for breast cancer and other solid tumors.Pharmacology & therapeutics · 2020Review
- Integrated Analysis of Structural Variation and RNA Expression of FGFR2 and Its Splicing Modulator ESRP1 Highlight theCancers · 2019Article
- Fibroblast Growth Factor Receptors Function Redundantly During Zebrafish Embryonic Development.Genetics · 2019Article
- Roles of FGFR in oral carcinogenesis.Cell proliferation · 2016Review
- Wnt and FGF mediated epithelial-mesenchymal crosstalk during lung development.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Review
- Receptor tyrosine kinase signaling: regulating neural crest development one phosphate at a time.Current topics in developmental biology · 2015Review
- Receptor tyrosine kinase (RTK) signalling in the control of neural stem and progenitor cell (NSPC) development.Molecular neurobiology · 2014Review
- Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology.Cold Spring Harbor perspectives in biology · 2013Review
- Exploring mechanisms of FGF signalling through the lens of structural biology.Nature reviews. Molecular cell biology · 2013Review
- Activating somatic FGFR2 mutations in breast cancer.PloS one · 2013Article
- Plasticity in interactions of fibroblast growth factor 1 (FGF1) N terminus with FGF receptors underlies promiscuity of FGF1.The Journal of biological chemistry · 2012Article
- Detection of isoform-specific fibroblast growth factor receptors by whole-mount in situ hybridization in early chick embryos.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Influence of heparin mimetics on assembly of the FGF.FGFR4 signaling complex.The Journal of biological chemistry · 2010Article
- Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform.The Journal of biological chemistry · 2009Article
- Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway.Molecular and cellular biology · 2007Article
- Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- NMR structure of the first Ig module of mouse FGFR1.Protein science : a publication of the Protein Society · 2006Article
- Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice.Molecular and cellular biology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Binding of cellular growth factors to their receptors constitutes a highly specific interaction and the basis for cell and tissue-type specific growth and differentiation. A unique feature of fibroblast growth factor (FGF) receptors is the multitude of structural variants and an unprecedented degree of cross-reactivity between receptors and their various ligands. To examine receptor-ligand specificity within these families of growth factors and receptors, we used genetic engineering to substitute discrete regions between Bek/FGFR2 and the closely related keratinocyte growth factor receptor (KGFR). We demonstrate that a confined, 50 amino acid, variable region within the third immunoglobulin-like domain of Bek and KGFR exclusively determines their ligand binding specificities. Replacing the variable region of Bek/FGFR2 with the corresponding sequence of KGFR resulted in a chimeric receptor which bound KGF and had lost the capacity to bind basic FGF. We present evidence that the two variable sequences are encoded by two distinct exons that map close together in the mouse genome and follow a constant exon, suggesting that the two receptors were derived from a common gene by mutually exclusive alternative mRNA splicing. These results identify the C-terminal half of the third immunoglobulin-like domain of FGF receptors as a major determinant for ligand binding and present a novel genetic mechanism for altering receptor-ligand specificity and generating receptor diversity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.