ArticleThe Biochemical journal1992
Transcriptional regulation of transferrin and albumin genes by retinoic acid in human hepatoma cell line Hep3B.
Article in The Biochemical journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 35 citations in OpenAlex.
- Redox-Regulated Iron Metabolism and Ferroptosis in Ovarian Cancer: Molecular Insights and Therapeutic Opportunities.Antioxidants (Basel, Switzerland) · 2024Review
- Dry age-related macular degeneration like pathology in aged 5XFAD mice: Ultrastructure and microarray analysis.Oncotarget · 2017Article
- Retinoic acid and cancer treatment.BioMedicine · 2014Article
- Retinoic Acid Induces Apoptosis of Prostate Cancer DU145 Cells through Cdk5 Overactivation.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- All-trans retinoic acid down-regulates human albumin gene expression through the induction of C/EBPbeta-LIP.The Biochemical journal · 2006Article
- Induction of P-glycoprotein mRNA transcripts by cycloheximide in animal tissues: evidence that class I Pgp is transcriptionally regulated whereas class II Pgp is post-transcriptionally regulated.Molecular and cellular biochemistry · 2001Article
- Enhanced expression of glucose-6-phosphate dehydrogenase in human cells sustaining oxidative stress.The Biochemical journal · 1997Article
- Suppression of albumin enhancer activity by H-ras and AP-1 in hepatocyte cell lines.Molecular and cellular biology · 1994Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transferrin and albumin, which are both secreted from the human hepatoma cell line Hep3B, were regulated transcriptionally by retinoic acid (RA) in a dose-dependent manner. The cell growth rate was little affected under the same conditions. The treatment of Hep3B cells with RA (10 microM for 48 h) resulted in an 8-fold increase in transferrin protein synthesis, a 10-fold increase in the steady-state transferrin mRNA level, and a 5-fold increase in its transcriptional rate. The same treatment led to 4-fold decrease in albumin synthesis, as well as a 7-fold decline in the steady-state albumin mRNA level and a 4-fold decrease in the transcriptional rate. Cycloheximide and actinomycin D blocked the action of RA, suggesting that RA may regulate transferrin and albumin gene expression indirectly in human liver cells.
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