ArticleThe American journal of pathology1992
Presence of Epstein-Barr virus in Hodgkin's disease is not exclusive to Reed-Sternberg cells.
Article in The American journal of pathology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 74 citations in OpenAlex.
- State of the Art and Future Challenges in Multiple Sclerosis Research and Medical Management: An Insight into the 5th International Porto Congress of Multiple Sclerosis.Neurology and therapy · 2020Review
- Epstein-Barr virus is present in the brain of most cases of multiple sclerosis and may engage more than just B cells.PloS one · 2018Article
- No evidence for the presence of Epstein-Barr virus in squamous cell carcinoma of the mobile tongue.PloS one · 2017Article
- Association of single nucleotide polymorphism rs2065955 of the filaggrin gene with susceptibility to Epstein-Barr virus-associated gastric carcinoma and EBV-negative gastric carcinoma.Virologica Sinica · 2016Article
- Effects of lymphocyte profile on development of EBV-induced lymphoma subtypes in humanized mice.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Global burden of deaths from Epstein-Barr virus attributable malignancies 1990-2010.Infectious agents and cancer · 2014Article
- Epstein-Barr virus in the multiple sclerosis brain: a controversial issue--report on a focused workshop held in the Centre for Brain Research of the Medical University of Vienna, Austria.Brain : a journal of neurology · 2011Article
- Is Epstein-Barr virus associated with aggressive forms of breast cancer?British journal of cancer · 2011Article
- Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt.Journal of hematopathology · 2010Article
- Further investigation of the role of HLA-DPB1 in adult Hodgkin's disease (HD) suggests an influence on susceptibility to different HD subtypes.British journal of cancer · 1999Article
- Rapid simultaneous amplification and detection of the MBR/JH chromosomal translocation by fluorescence melting curve analysis.The American journal of pathology · 1999Article
- Down-regulation of Epstein-Barr virus nuclear antigen 1 in Reed-Sternberg cells of Hodgkin's disease.Journal of clinical pathology · 1995Article
- Detection and characterization of Epstein-Barr virus in clinical specimens.The American journal of pathology · 1994Review
- Epstein-Barr virus infection and bcl-2 proto-oncogene expression. Separate events in the pathogenesis of Hodgkin's disease?The American journal of pathology · 1993Article
- Association of Epstein-Barr virus with pediatric Hodgkin's disease.The American journal of pathology · 1993Article
- Epstein-Barr virus and Hodgkin's disease: transcriptional analysis of virus latency in the malignant cells.The Journal of experimental medicine · 1993Article
- p53 expression in Reed-Sternberg cells of Hodgkin's disease.British journal of cancer · 1992Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thirty-three cases of Hodgkin's disease (HD) have been studied for the presence of Epstein-Barr virus (EBV) using a novel nonisotopic in situ hybridization procedure, based on the detection of Epstein-Barr encoded RNAs with oligonucleotide probes. An intense and morphologically distinct nuclear staining, sparing the nucleolus was seen in a total of 12 cases (36%). In six of these cases, the signal was located to the Hodgkin and Reed-Sternberg cells (HR-S); in the other six positive cases, the signal was observed only in the non-neoplastic small lymphocytes. These lymphocytes were few in number and immunocytochemistry results were consistent with a B-cell phenotype. The presence of EBV in those cases characterized by nuclear staining of small lymphocytes was confirmed by the polymerase chain reaction (PCR) analysis. The authors report the detection of EBV in small lymphocytes in HD by in situ hybridization and discuss the implications of these findings in relation to the proposed etiologic association between EBV and HD.
Indexed as
Identifiers
1314022PMC1886366W1413577309What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.