ArticleJournal of virology1992
Infection of HeLa cells with poliovirus results in modification of a complex that binds to the rRNA promoter.
Article in Journal of virology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Exploitation of nuclear functions by human rhinovirus, a cytoplasmic RNA virus.PLoS pathogens · 2018Article
- Picornaviruses and nuclear functions: targeting a cellular compartment distinct from the replication site of a positive-strand RNA virus.Frontiers in microbiology · 2015Review
- Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis.The Journal of biological chemistry · 2011Article
- Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion.The EMBO journal · 2010Article
- Translational control by viral proteinases.Virus research · 2006Review
- Regulation of poliovirus 3C protease by the 2C polypeptide.Journal of virology · 2004Article
- Bidirectional increase in permeability of nuclear envelope upon poliovirus infection and accompanying alterations of nuclear pores.Journal of virology · 2004Article
- The interaction of animal cytoplasmic RNA viruses with the nucleus to facilitate replication.Virus research · 2003Review
- Antiviral effects of pyrrolidine dithiocarbamate on human rhinoviruses.Journal of virology · 2002Article
- Cytopathogenesis and inhibition of host gene expression by RNA viruses.Microbiology and molecular biology reviews : MMBR · 2000Review
- Selective irreversible inactivation of replicating mengovirus by nucleoside analogues: a new form of viral interference.Journal of virology · 1999Article
- Regulation of RNA polymerase I-dependent promoters by the hepatitis B virus X protein via activated Ras and TATA-binding protein.Molecular and cellular biology · 1998Article
- Inhibition of endoplasmic reticulum-to-Golgi traffic by poliovirus protein 3A: genetic and ultrastructural analysis.Journal of virology · 1997Article
- Poliovirus-encoded protease 2APro cleaves the TATA-binding protein but does not inhibit host cell RNA polymerase II transcription in vitro.Journal of virology · 1997Article
- Inhibition of host cell transcription by poliovirus: cleavage of transcription factor CREB by poliovirus-encoded protease 3Cpro.Journal of virology · 1997Article
- Induction of HSP70 and polyubiquitin expression associated with plant virus replication.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Inhibition of basal transcription by poliovirus: a virus- encoded protease (3Cpro) inhibits formation of TBP-TATA box complex in vitro.Journal of virology · 1996Article
- Inhibition of cellular protein secretion by poliovirus proteins 2B and 3A.The EMBO journal · 1995Article
- Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes.Microbiological reviews · 1993Review
- Picornavirus nonstructural proteins: emerging roles in virus replication and inhibition of host cell functions.Journal of virology · 1993Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In HeLa cells, RNA polymerase I (Pol I)-mediated transcription is severely inhibited soon after infection with poliovirus. We have developed a gel retardation assay to analyze DNA-protein complexes formed at the Pol I promoter. We show here that two complexes (A and C) formed by nuclear extracts from uninfected cells disappear after infection of cells with poliovirus. In contrast, a new, rapidly migrating complex (D) is formed in virus-infected cell extract. This change in the mobility of gel-retarded complexes correlates well with the kinetics of inhibition of rRNA transcription in virus-infected cells. Incubation of nuclear extracts from mock-infected cells with bacterially expressed, purified poliovirus protease 3C results in the disappearance of complexes A and C with concomitant generation of complex D. A partially purified transcription factor fraction derived from uninfected cells that contains complex A is able to restore Pol I transcription when added to virus-infected cell extracts, suggesting that this complex plays an important role in Pol I transcription. These results suggest that poliovirus proteinase 3C may have an important role in the shutoff of Pol I transcription in cells infected with poliovirus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.