ArticleThe Journal of cell biology1992
Astrocyte process growth induction by actin breakdown.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 141 citations in OpenAlex.
- Molecular Motors in Blood-Brain Barrier Maintenance by Astrocytes.Brain sciences · 2025Review
- Astrocytic Calcium Signaling Toolkit (astroCaST): efficient analysis of dynamic astrocytic calcium events.Frontiers in cellular neuroscience · 2024Article
- The role of astrocyte structural plasticity in regulating neural circuit function and behavior.Glia · 2022Review
- Design of an Imaging Probe to Monitor Real-Time Redistribution of L-type Voltage-Gated Calcium Channels in Astrocytic Glutamate Signaling.Molecular imaging and biology · 2021Article
- A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models.Nature communications · 2017Article
- Astrocytic GAP43 Induced by the TLR4/NF-κB/STAT3 Axis Attenuates Astrogliosis-Mediated Microglial Activation and Neurotoxicity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- New advances on glial activation in health and disease.World journal of virology · 2015Review
- Functional role of RNA polymerase II and P70 S6 kinase in KCl withdrawal-induced cerebellar granule neuron apoptosis.The Journal of biological chemistry · 2015Article
- Profilin isoforms modulate astrocytic morphology and the motility of astrocytic processes.PloS one · 2015Article
- Inhibition of Myosin light-chain kinase attenuates cerebral edema after traumatic brain injury in postnatal mice.Journal of neurotrauma · 2013Article
- Alteration of astrocytes and Wnt/β-catenin signaling in the frontal cortex of autistic subjects.Journal of neuroinflammation · 2012Article
- Cell rounding in cultured human astrocytes and vascular endothelial cells upon inhibition of CK2 is mediated by actomyosin cytoskeleton alterations.Journal of cellular biochemistry · 2012Article
- Albumin causes increased myosin light chain kinase expression in astrocytes via p38 mitogen-activated protein kinase.Journal of neuroscience research · 2011Article
- The Rho kinase inhibitor Fasudil up-regulates astrocytic glutamate transport subsequent to actin remodelling in murine cultured astrocytes.British journal of pharmacology · 2011Article
- Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition.Hepatology (Baltimore, Md.) · 2009Article
- Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Detyrosinated microtubule protrusions in suspended mammary epithelial cells promote reattachment.Experimental cell research · 2007Article
- Activity of cofilin can be regulated by a mechanism other than phosphorylation/dephosphorylation in muscle cells in culture.Journal of muscle research and cell motility · 2007Article
- Process outgrowth in oligodendrocytes is mediated by CNP, a novel microtubule assembly myelin protein.The Journal of cell biology · 2005Article
- The effect of dibutyryl cyclic AMP on the expression of actin isoforms in astroglia.The Histochemical journal · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
cAMP analogues such as dibutyryl cAMP (dBcAMP) have been shown to induce the formation of processes in cultured primary astrocytes. We observe that the processes form by elongation as well as the previously reported retraction of cytoplasm around cytoskeletal elements. The most prominent cytoskeletal change that occurs in response to dBcAMP is a rearrangement of actin filaments characterized by a loss of cortical F-actin staining and the appearance of actin filament staining at the tips of the processes. If cortical actin filaments are disrupted with dihydrocytochalasin B, processes form that are similar to those induced by dBcAMP suggesting that the disruption of the cortical actin network is the pivotal step in process formation. Reorganization of the actin filament network in response to cAMP is accompanied by a decrease in phosphate incorporation into the regulatory light chain of myosin (MLC). Two selective inhibitors of MLC kinase (MLCK), ML-9 and KT5926, as well as a calmodulin antagonist (W7), which would also inhibit MLCK activation, all induce astrocytic process growth implicating MLCK as a control point in process initiation. We also found that dBcAMP and ML-9 both cause a decrease in the phosphate content of actin depolymerizing factor, suggesting that this protein and myosin light chain are the effectors of actin cytoskeleton reorganization and process growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.