ArticleBritish journal of pharmacology1992
Bradykinin receptors in the guinea-pig taenia caeci are similar to proposed BK3 receptors in the guinea-pig trachea, and are blocked by HOE 140.
Article in British journal of pharmacology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- A study of the action of bradykinin and bradykinin analogues in the human nasal airway.The Journal of physiology · 1994Trial
- Kinin B1- and B2-Receptor Subtypes Contract Isolated Bovine Ciliary Muscle: Their Role in Ocular Lens Function and Intraocular Pressure Reduction.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Characterization of kinin receptors modulating neurogenic contractions of the mouse isolated vas deferens.British journal of pharmacology · 1995Article
- Bradykinin B1 receptors in the rabbit urinary bladder: induction of responses, smooth muscle contraction, and phosphatidylinositol hydrolysis.British journal of pharmacology · 1995Article
- Involvement of B2 receptors in the bradykinin-induced relaxation of guinea-pig isolated trachea.British journal of pharmacology · 1995Article
- Bradykinin B2 receptors and coupling mechanisms in the smooth muscle of the guinea-pig taenia caeci.British journal of pharmacology · 1994Article
- The action of Hoe 140 on the bradykinin-induced splenic pressor reflex of the anaesthetized cat.British journal of pharmacology · 1993Article
- Role played by NK2 receptor and cyclooxygenase activation in bradykinin B2 receptor mediated-airway effects in guinea pigs.Agents and actions · 1993Article
- Evidence for the involvement of bradykinin in chemically-evoked cystitis in anaesthetized rats.Naunyn-Schmiedeberg's archives of pharmacology · 1993Article
- Antagonism of kinin effects on epithelial by Hoe 140: apparently competitive and non-competitive interactions.British journal of pharmacology · 1992Article
- Bradykinin B2 receptor-mediated phosphoinositide hydrolysis in bovine cultured tracheal smooth muscle cells.British journal of pharmacology · 1992Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
1. Bradykinin (BK) receptors of the guinea-pig taenia caeci were compared with those of the guinea-pig trachea, a preparation proposed to possess novel BK3 receptors. 2. Bradykinin-evoked contractile responses were unaffected in both preparations by the selective BK1 receptor antagonist [des-Arg9,Leu8]-BK (1 microM-10 microM). The BK2 receptor antagonists, D-Arg-[Hyp3,D-Phe7]-BK and D-Arg-[Hyp3,Thi5,8,D-Phe7]-BK, both had low affinities (apparent pKB estimates less than 6) which did not differ significantly between the two preparations (P greater than 0.05). In contrast, the novel bradykinin receptor antagonist D-Arg-[Hyp3,Thi5,D-Tic7,Oic8]-BK (HOE 140) potently antagonized responses to bradykinin with relatively high affinity (apparent pKB = 8.42 +/- 0.15 and 8.94 +/- 0.16 in the taenia caeci, and trachea, respectively). 3. We conclude that the bradykinin receptors in the guinea-pig taenia caeci have similar recognition properties to those present in the guinea-pig trachea, and in this respect the taenia caeci represents a useful preparation for the further study of proposed novel BK3 receptors.
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