ArticleProceedings of the National Academy of Sciences of the United States of America1992
K-sam gene encodes secreted as well as transmembrane receptor tyrosine kinase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 65 citations in OpenAlex.
- Fibroblast growth factor receptor signaling as therapeutic targets in gastric cancer.World journal of gastroenterology · 2016Review
- Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers.Apoptosis : an international journal on programmed cell death · 2013Review
- Cancer-stromal interactions in scirrhous gastric carcinoma.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2010Article
- Cellular and molecular aspects of gastric cancer.World journal of gastroenterology · 2006Review
- Differential gene expression profiles of gastric cancer cells established from primary tumour and malignant ascites.British journal of cancer · 2002Article
- Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis.American journal of human genetics · 2002Article
- Tyrosine kinases and gastric cancer.Oncogene · 2000Review
- De novo alu-element insertions in FGFR2 identify a distinct pathological basis for Apert syndrome.American journal of human genetics · 1999Article
- Overexpression of bone morphogenic protein (BMP)-4 mRNA in gastric cancer cell lines of poorly differentiated type.Journal of gastroenterology · 1996Article
- Effective prevention of thrombocytopenia in mice using adenovirus-mediated transfer of HST-1 (FGF-4) gene.The Journal of clinical investigation · 1995Article
- A truncated K-sam product lacking the distal carboxyl-terminal portion provides a reduced level of autophosphorylation and greater resistance against induction of differentiation.Molecular and cellular biology · 1995Article
- Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors.Annals of surgical oncology · 1994Article
- Expression of transforming growth factor-beta receptor type II gene in gastric cancer cell lines.Gastroenterologia Japonica · 1993Article
- Control of BEK and K-SAM splice sites in alternative splicing of the fibroblast growth factor receptor 2 pre-mRNA.Molecular and cellular biology · 1993Article
- Cloning of two novel forms of human acidic fibroblast growth factor (aFGF) mRNA.Nucleic acids research · 1993Article
- Molecular mechanism of stomach carcinogenesis.Journal of cancer research and clinical oncology · 1993Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1992Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
K-sam was first identified as a gene amplified in the stomach cancer cell line KATO-III. The size of the major transcript of the K-sam gene was 3.5 kilobases in KATO-III cells, and we have previously shown that K-sam encodes a receptor tyrosine kinase that belongs to the heparin-binding growth factor receptor, or fibroblast growth factor receptor, gene family. The K-sam gene expresses multiple sizes of mRNAs in brain tissue, the immature teratoma cell line NCC-IT, and KATO-III. RNA blot analyses with a variety of K-sam probes indicate that there are at least four classes of K-sam mRNAs. Three types of K-sam cDNAs in addition to the previously reported type of K-sam cDNA were isolated, and their nucleotide sequences encode a full-length transmembrane receptor, a secreted receptor with a tyrosine kinase domain, and a secreted receptor without a tyrosine kinase domain.
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