ArticleProceedings of the National Academy of Sciences of the United States of America1992
Plasma membrane inositol 1,4,5-trisphosphate receptor of lymphocytes: selective enrichment in sialic acid and unique binding specificity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 119 citations in OpenAlex.
- Molecular basis of calcium signaling in lymphocytes: STIM and ORAI.Annual review of immunology · 2010Review
- Ca(2+) channels on the move.Biochemistry · 2009Review
- Protein-tyrosine phosphatase-alpha and Src functionally link focal adhesions to the endoplasmic reticulum to mediate interleukin-1-induced Ca2+ signaling.The Journal of biological chemistry · 2009Article
- The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells.The Biochemical journal · 2003Article
- An inositol 1,4,5-trisphosphate receptor-dependent cation entry pathway in DT40 B lymphocytes.The EMBO journal · 2002Article
- Inositol 1,4,5-trisphosphate receptors in endocrine cells: localization and association in hetero- and homotetramers.Molecular biology of the cell · 1996Article
- Inositol 1,4,5-trisphosphate-gated calcium transport through plasma membranes in nerve terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm.The Journal of cell biology · 1995Article
- Calcium and inositol trisphosphate receptors.The Journal of membrane biology · 1995Review
- Histamine-induced Ca2+ entry precedes Ca2+ mobilization in bovine adrenal chromaffin cells.The Biochemical journal · 1994Article
- Cyclic nucleotide- and inositol phosphate-gated ion channels in lobster olfactory receptor neurons.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- A large contribution of a cyclic AMP-independent pathway to turtle olfactory transduction.The Journal of general physiology · 1994Article
- A slowly ADP-ribosylated pertussis-toxin-sensitive GTP-binding regulatory protein is required for vasopressin-stimulated Ca2+ inflow in hepatocytes.The Biochemical journal · 1994Article
- Specific binding sites for inositol 1,3,4,5-tetrakisphosphate are located predominantly in the plasma membranes of human platelets.The Biochemical journal · 1994Article
- Characterization of receptor-mediated and store-regulated Ca2+ influx in human neutrophils.The Biochemical journal · 1994Article
- Comparative localization of inositol 1,4,5-trisphosphate and ryanodine receptors in intestinal smooth muscle: an analytical subfractionation study.The Biochemical journal · 1994Article
- Isolation and characterization of membrane potential changes associated with release of calcium from intracellular stores in rat thymic lymphocytes.The Journal of membrane biology · 1994Article
- Non-oscillatory free Ca2+ response of single B cells and WEHI-231 cells after cross-linking of antigen receptors with anti-immunoglobulin.Immunology · 1993Article
- Signalling through CD28 T-cell activation pathway involves an inositol phospholipid-specific phospholipase C activity.The Biochemical journal · 1993Article
- Two independently regulated Ca2+ entry mechanisms coexist in Jurkat T cells during T cell receptor antigen activation.The Biochemical journal · 1993Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The inositol 1,4,5-trisphosphate receptor (IP3R) associated with plasma membranes of lymphocytes differs in terminal sugar content and binding specificity from the cerebellar receptor, which is localized to endoplasmic reticulum. Lectin column chromatography reveals that 30% of IP3R in the thymus contains sialic acid, reflecting a plasma membrane association, in contrast to 5% of cerebellar IP3R. IP3R in thymus and plasma membrane fractions of Jurkat lymphocytes differs from IP3R of Jurkat microsomes and cerebellum in inositol phosphate specificity. The plasma membrane IP3R has lower affinity for IP3 but higher affinity for inositol 1,3,4,5-tetrakisphosphate, which may reflect a unique regulation of calcium at the plasma membrane by inositol phosphates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.