ArticleBritish heart journal1992
Beta endorphin release in patients after spontaneous and provoked acute myocardial ischaemia.
Article in British heart journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review.Arquivos brasileiros de cardiologia · 2015Pooled it
- Activation and inhibition of the endogenous opioid system in human heart failure.British heart journal · 1995Trial
- Recent advances in the management of chronic stable angina II. Anti-ischemic therapy, options for refractory angina, risk factor reduction, and revascularization.Vascular health and risk management · 2010Review
- Treatment with double dose of omeprazole increases β-endorphin plasma level in patients with coronary artery disease.Archives of medical science : AMS · 2010Article
- Hypothalamo-pituitary-adrenal axis in acute myocardial infarction treated by percutaneous transluminal coronary angioplasty: effect of time of presentation.Journal of endocrinological investigation · 2003Article
- Spinal cord stimulation for chronic intractable angina pectoris: a unified theory on its mechanism.Clinical cardiology · 2001Review
- Increase in plasma beta endorphins precedes vasodepressor syncope.British heart journal · 1994Article
- Failure to reproduce the in vitro cardiac electrophysiological effects of naloxone in humans.British journal of clinical pharmacology · 1994Article
- B-endorphin release in patients after spontaneous and provoked acute myocardial ischemia.British heart journal · 1993Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn animal models of circulatory shock and heart failure concentrations of the endogenous opioid peptide beta endorphin are raised and opioid receptor blockade improves haemodynamic variables and survival. This study was performed to identify whether acute myocardial ischaemia provokes the release of beta endorphin in humans.
methodsObservational study in a university cardiology centre. Serial measurements of beta endorphin made by specific radioimmunoassay were correlated with other clinical and neuroendocrine variables that were measured prospectively. Fifty five patients with acute myocardial ischaemia and 26 patients undergoing elective coronary angioplasty of the left anterior descending coronary artery were studied.
resultsbeta endorphin concentrations were raised above the upper limit of normal in 31/42 (74%) patients with confirmed myocardial infarction, 3/13 (23%) patients with unstable angina, and 10/24 (42%) patients after coronary angioplasty. There was no evidence of myocardial release of beta endorphin. There were significant positive correlations between beta endorphin and the concentrations of adrenocorticotrophic hormone, cortisol, and arginine vasopressin. In patients with acute myocardial ischaemia there was a significant positive correlation between the peak concentrations of creatine kinase and beta endorphin but no correlation with visual analogue scores of the intensity of chest pain. The highest beta endorphin concentrations were seen in patients whose clinical course was complicated by the development of heart failure.
conclusionsbeta endorphin release is a component of the neuroendocrine activation associated with myocardial ischaemia/infarction.
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