ArticleBone marrow transplantation2003
Complete recovery from Cryptosporidium parvum infection with gastroenteritis and sclerosing cholangitis after successful bone marrow transplantation in two brothers with X-linked hyper-IgM syndrome.
Article in Bone marrow transplantation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 47 citations in OpenAlex.
- Cryptosporidiosis in inborn errors of immunity: a single center cohort and review of the literature.The Journal of infectious diseases · 2026Article
- Innate Immunity Stimulation during the COVID-19 Pandemic: Challenge by Parvulan.Journal of immunology research · 2022Article
- Gastrointestinal Manifestations and Complications of Primary Immunodeficiency Disorders.Immunology and allergy clinics of North America · 2019Review
- Cryptosporidium parvum induces SIRT1 expression in host epithelial cells through downregulating let-7i.Human immunology · 2014Article
- Diagnosis and treatment of gastrointestinal disorders in patients with primary immunodeficiency.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2013Review
- Update on the hyper immunoglobulin M syndromes.British journal of haematology · 2010Review
- Pathogenesis and treatment of gastrointestinal disease in antibody deficiency syndromes.The Journal of allergy and clinical immunology · 2009Review
- HIV-1 Tat protein suppresses cholangiocyte toll-like receptor 4 expression and defense against Cryptosporidium parvum.The Journal of infectious diseases · 2009Article
- Genotyping of Cryptosporidium isolates from human clinical cases in Poland.Parasitology research · 2008Article
- X-linked hyper-IgM syndrome associated with poorly differentiated neuroendocrine tumor presenting as obstructive jaundice secondary to extensive adenopathy.Digestive diseases and sciences · 2007Article
- The human immunodeficiency virus type 1 tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism.Infection and immunity · 2007Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe two brothers who suffered from hyper-IgM syndrome (HIGM1) with similar clinical features: recurrent infections, especially cryptosporidium gastroenteritis with cholangitis. Their activated T cells did not express CD40L. Nucleotide sequencing revealed a mutation in both boys with respect to intron 4 and exon 5 boundaries of the CD40L gene in Xq26. They underwent successful bone marrow transplantation (BMT) from HLA-geno-identical siblings. The Cryptosporidium infection and cholangitis resolved thereafter. At 6 months after BMT, expression of CD40L on activated T lymphocytes was normal. After 1 year, both boys are well, and immune reconstitution has improved. Based on these two successful experiences, BMT with a genoidentical sibling seems a reasonable therapeutic approach for HIGM1, if Cryptosporidium infection occurs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.