ArticleJournal of bacteriology2003
VGJ phi, a novel filamentous phage of Vibrio cholerae, integrates into the same chromosomal site as CTX phi.
Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- The Life Cycle Transitions of Temperate Phages: Regulating Factors and Potential Ecological Implications.Viruses · 2022Review
- Functional Analysis of theAntibiotics (Basel, Switzerland) · 2020Article
- Beyond Cholera: Characterization ofViruses · 2020Article
- Genetically similar temperate phages form coalitions with their shared host that lead to niche-specific fitness effects.The ISME journal · 2020Article
- Filamentous phages: masters of a microbial sharing economy.EMBO reports · 2019Review
- Similarities and Differences between Colicin and Filamentous Phage Uptake by Bacterial Cells.EcoSal Plus · 2019Review
- Widespread distribution of prophage-encoded virulence factors in marine Vibrio communities.Scientific reports · 2018Article
- CTXφ Replication Depends on the Histone-Like HU Protein and the UvrD Helicase.PLoS genetics · 2015Article
- Two different evolutionary lines of filamentous phages in Ralstonia solanacearum: their effects on bacterial virulence.Frontiers in genetics · 2015Article
- Neisseria gonorrhoeae filamentous phage NgoΦ6 is capable of infecting a variety of Gram-negative bacteria.Journal of virology · 2014Article
- Mechanistic insights into filamentous phage integration in Vibrio cholerae.Frontiers in microbiology · 2014Review
- The filamentous phage XacF1 causes loss of virulence in Xanthomonas axonopodis pv. citri, the causative agent of citrus canker disease.Frontiers in microbiology · 2014Article
- Isolation and characterization of the new mosaic filamentous phage VFJ Φ of Vibrio cholerae.PloS one · 2013Article
- Filamentous phages of Ralstonia solanacearum: double-edged swords for pathogenic bacteria.Frontiers in microbiology · 2013Article
- Review
- Holliday junction affinity of the base excision repair factor Endo III contributes to cholera toxin phage integration.The EMBO journal · 2012Article
- Site-specific recombination systems in filamentous phages.Molecular genetics and genomics : MGG · 2012Review
- Characterization of Vibrio cholerae O139 of an Aquatic Isolate in Northern Vietnam.The open microbiology journal · 2012Article
- High frequency of a novel filamentous phage, VCY φ, within an environmental Vibrio cholerae population.Applied and environmental microbiology · 2012Article
- VGJphi integration and excision mechanisms contribute to the genetic diversity of Vibrio cholerae epidemic strains.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
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9 authors.
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Abstract
We describe a novel filamentous phage, designated VGJ phi, isolated from strain SG25-1 of Vibrio cholerae O139, which infects all O1 (classical and El Tor) and O139 strains tested. The sequence of the 7,542 nucleotides of the phage genome reveals that VGJ phi has a distinctive region of 775 nucleotides and a conserved region with an overall genomic organization similar to that of previously characterized filamentous phages, such as CTX phi of V. cholerae and Ff phages of Escherichia coli. The conserved region carries 10 open reading frames (ORFs) coding for products homologous to previously reported peptides of other filamentous phages, and the distinctive region carries one ORF whose product is not homologous to any known peptide. VGJ phi, like other filamentous phages, uses a type IV pilus to infect V. cholerae; in this case, the pilus is the mannose-sensitive hemagglutinin. VGJ phi-infected V. cholerae overexpresses the product of one ORF of the phage (ORF112), which is similar to single-stranded DNA binding proteins of other filamentous phages. Once inside a cell, VGJ phi is able to integrate its genome into the same chromosomal attB site as CTX phi, entering into a lysogenic state. Additionally, we found an attP structure in VGJ phi, which is also conserved in several lysogenic filamentous phages from different bacterial hosts. Finally, since different filamentous phages seem to integrate into the bacterial dif locus by a general mechanism, we propose a model in which repeated integration events with different phages might have contributed to the evolution of the CTX chromosomal region in V. cholerae El Tor.
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