ArticleJapanese journal of cancer research : Gann1992
mRNA levels of catalytic subunits of protein phosphatases 1, 2A, and 2C in hepatocarcinogenesis.
Article in Japanese journal of cancer research : Gann, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 20 citations in OpenAlex.
- Gene expressions of protein tyrosine phosphatases in regenerating rat liver and rat ascites hepatoma cells.Japanese journal of cancer research : Gann · 1995Article
- Mapping of the genes for rat protein phosphatase 2A alpha (PP2A1) and 2A beta (PP2A2) to chromosomes 10 and 16, respectively.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- Selective increases in isoform PP1 alpha of type-1 protein phosphatase in ascites hepatoma cells.Japanese journal of cancer research : Gann · 1994Article
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8 authors at 6 institutions in 3 countries.
Funding
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Abstract
The mRNA levels of three phosphoseryl/phosphothreonyl protein phosphatases, PP1, PP2A and PP2C, in rat liver have been determined by Northern blot analysis in various stages of rat chemical hepatocarcinogenesis using a Solt-Farber model. Five weeks after administration of diethylnitrosamine, the mRNA levels of PP1 alpha, PP2A and PP2C were elevated 8, 29 and 11 times, respectively, as compared to those of the control livers. However, in primary hepatoma induced according to the Solt-Farber model, the mRNA levels of all three protein phosphatases were dramatically decreased to normal levels or even to much lower levels, whereas the mRNA level of glutathione S-transferase placental form, a tumor marker protein, was greatly elevated as compared with that of the control livers. In a poorly differentiated hepatoma AH13, a line of rat ascites hepatoma, the mRNA level of PP1 alpha was 5.6 times higher than that of the control livers, whereas the mRNA lever of PP2C was almost the same as that of the control livers and the level of PP2A mRNA was distinctly lower than that of the control livers. These data appear to suggest some involvement of protein phosphatases in hepatocarcinogenesis.
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