ArticleThe Journal of cell biology1992
Cortical localization of a calcium release channel in sea urchin eggs.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 118 citations in OpenAlex.
- Regulation of the Actin Cytoskeleton-Linked CaCells · 2022Article
- Carvedilol inhibits cADPR- and IPMessenger (Los Angeles, Calif. : Print) · 2016Article
- Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles.The Journal of cell biology · 2013Article
- Article
- Molecular biology of insect olfaction: recent progress and conceptual models.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2005Review
- Detection and functional characterization of ryanodine receptors from sea urchin eggs.The Journal of physiology · 1998Article
- A localized elevation of cytosolic free calcium is associated with cytokinesis in the zebrafish embryo.The Journal of cell biology · 1995Article
- The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.The Journal of cell biology · 1995Article
- Ca2+ release from subplasmalemmal stores as a primary event during exocytosis in Paramecium cells.The Journal of cell biology · 1994Article
- Cyclic ADP-ribose: a calcium mobilizing metabolite of NAD+.Molecular and cellular biochemistry · 1994Review
- Calcium release-activated calcium current in rat mast cells.The Journal of physiology · 1993Article
- Inositol 1,4,5-trisphosphate mass changes from fertilization through first cleavage in Xenopus laevis.Molecular biology of the cell · 1993Article
- Endoplasmic reticulum: a dynamic patchwork of specialized subregions.Molecular biology of the cell · 1992Review
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
We have used an antibody against the ryanodine receptor/calcium release channel of skeletal muscle sarcoplasmic reticulum to localize a calcium release channel in sea urchin eggs. The calcium release channel is present in less than 20% of immature oocytes, where it does not demonstrate a specific cytoplasmic localization, while it is confined to the cortex of all mature eggs examined. This is in contrast to the cortical and subcortical localization of calsequestrin in mature and immature eggs. Immunolocalization of the calcium release channel reveals a cortical reticulum or honeycomb staining network that surrounds cortical granules and is associated with the plasma membrane. The network consists of some immunoreactive electron-dense material coating small vesicles and elongate cisternae of the endoplasmic reticulum. The fluorescent reticular staining pattern is lost when egg cortices are treated with agents known to affect sarcoplasmic reticulum calcium release and induce cortical granule exocytosis (ryanodine, calcium, A-23187, and caffeine). An approximately 380-kD protein of sea urchin egg cortices is identified by immunoblot analysis with the ryanodine receptor antibody. These results demonstrate: (a) the presence of a ryanodine-sensitive calcium release channel that is located within the sea urchin egg cortex; (b) an altered calcium release channel staining pattern as a result of treatments that initiate the cortical granule reaction; and (c) a spatial and functional dichotomy of the ER which may be important in serving different roles in the mobilization of calcium at fertilization.
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Registered trials
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