ArticleThe EMBO journal1992
Transcriptional regulation of the c-jun gene by retinoic acid and E1A during differentiation of F9 cells.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 80 citations in OpenAlex.
- c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells.Molecules (Basel, Switzerland) · 2017Article
- Unfavorable neuroblastoma prognostic factor NLRR2 inhibits cell differentiation by transcriptional induction through JNK pathway.Cancer science · 2016Article
- Phosphorylation of Activation Transcription Factor-2 at Serine 121 by Protein Kinase C Controls c-Jun-mediated Activation of Transcription.The Journal of biological chemistry · 2009Article
- Rapid effects of retinoic acid on CREB and ERK phosphorylation in neuronal cells.Molecular biology of the cell · 2004Article
- Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation.The EMBO journal · 2002Article
- JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells.Molecular and cellular biology · 2002Article
- Cloning and analysis of the mouse follistatin promoter.Molecular biology reports · 2000Article
- Differential regulation of the human nidogen gene promoter region by a novel cell-type-specific silencer element.The Biochemical journal · 1999Article
- The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1.Molecular and cellular biology · 1998Article
- p300 and ATF-2 are components of the DRF complex, which regulates retinoic acid- and E1A-mediated transcription of the c-jun gene in F9 cells.Genes & development · 1998Article
- CBP-induced stimulation of c-Fos activity is abrogated by E1A.The EMBO journal · 1995Article
- Phosphorylation of the adenovirus E1A-associated 300 kDa protein in response to retinoic acid and E1A during the differentiation of F9 cells.The EMBO journal · 1995Article
- AP-1, ETS, and transcriptional silencers regulate retinoic acid-dependent induction of keratin 18 in embryonic cells.Molecular and cellular biology · 1994Article
- A novel pathway for retinoic acid-induced differentiation of F9 cells that is distinct from receptor-mediated trans-activation.In vitro cellular & developmental biology. Animal · 1994Article
- The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulator.Molecular and cellular biology · 1994Article
- Cryptic promoter activity within the backbone of a plasmid commonly used to prepare promoter/reporter gene constructs.In vitro cellular & developmental biology. Animal · 1994Article
- Dominant negative retinoid X receptor beta inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells.Molecular and cellular biology · 1994Article
- Negative regulation of transcription in eukaryotes.The Biochemical journal · 1993Review
- Identification of positive and negative regulatory elements involved in the retinoic acid/cAMP induction of Fgf-3 transcription in F9 cells.Nucleic acids research · 1993Article
- Transactivation of mouse insulin-like growth factor II (IGF-II) gene promoters by the AP-1 complex.Nucleic acids research · 1993Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differentiation of mouse F9 embryonal carcinoma (EC) cells can be induced by exposure to retinoic acid (RA) or by expression of adenovirus E1A. The transcription of the c-jun gene is stimulated by either RA or E1A. We report here that both RA and E1A strongly induce the expression of chloramphenicol acetyltransferase (CAT) from c-jun promoter/CAT reporter construct (c-jun/CAT), which is stably integrated into F9 cells, in a manner that is independent of both copy number and integration locus. The induction of c-jun/CAT expression is observed in undifferentiated F9 cells, but not in differentiated F9 cells, adenovirus-infected F9 cells or HeLa cells. Deletion analysis of the promoter region of the c-jun gene indicates that the sequence elements required for the RA- and E1A-mediated induction are identical and they have been defined as a region of 145 bp between -190 and -46 of the 5' flanking region of c-jun. This RA and E1A response element (RERE) contains five variants of the motif CGCGGTGACGNT. The upstream two motifs are adjacent and extend in opposite directions, creating an imperfect palindrome. The downstream four motifs are located at 35 or 36 bp intervals in the same orientation. Substitution and insertion analysis indicates that these motifs and their regular intervals are important for the activity of the RERE.
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