ArticleClinical and experimental immunology1992
Variable gene usage of T cell receptor gamma- and delta-chain transcripts expressed in synovia and peripheral blood of patients with rheumatoid arthritis.
Article in Clinical and experimental immunology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 53 citations in OpenAlex.
- Review
- Observational
- Only a subset of phosphoantigen-responsive gamma9delta2 T cells mediate protective tuberculosis immunity.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Expression of T cell receptor variable region families by bone marrow gammadelta T cells in patients with IgA nephropathy.Clinical and experimental immunology · 2002Article
- Gamma delta T cell receptor analysis supports a role for HSP 70 selection of lymphocytes in multiple sclerosis lesions.Molecular medicine (Cambridge, Mass.) · 1995Article
- Gamma delta T cell receptor gene expression by muscle-infiltrating lymphocytes in the idiopathic inflammatory myopathies.Clinical and experimental immunology · 1995Article
- Predominance of T cell receptor V delta 3 in small bowel biopsies from coeliac disease patients.Clinical and experimental immunology · 1994Article
- Restricted junctional diversity of T cell receptor delta gene rearrangements expressed in systemic lupus erythematosus (SLE) patients.Clinical and experimental immunology · 1994Article
- Elevated numbers of gamma-delta (gamma delta+) T lymphocytes in children with immune thrombocytopenic purpura.Journal of clinical immunology · 1994Article
- T-cell antigen receptors in rheumatoid arthritis.Immunologic research · 1994Review
- The gamma delta T cell repertoire in Graves' disease and multinodular goitre.Clinical and experimental immunology · 1993Article
- Molecular heterogeneity of a Graves' thyroid-infiltrating T cell population rich in CD8+ and gamma delta+ T cells.Journal of endocrinological investigation · 1993Article
- Immunology of atherosclerosis. Demonstration of heat shock protein 60 expression and T lymphocytes bearing alpha/beta or gamma/delta receptor in human atherosclerotic lesions.The American journal of pathology · 1993Article
- Role of protein glycosylation in immune regulation.Annals of the rheumatic diseases · 1993Review
- A high proportion of the V delta 1+ synovial fluid gamma delta T cells in juvenile rheumatoid arthritis patients express the very early activation marker CD69, but carry the high molecular weight isoform of the leucocyte common antigen (CD45RA).Clinical and experimental immunology · 1993Article
- Regulation of the mature human T cell receptor gamma repertoire by biased V-J gene rearrangement.The Journal of clinical investigation · 1993Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The synovial tissue and fluid of patients with rheumatoid arthritis (RA) contain activated T cells that probably have a central role in the disease process which leads to joint destruction. A subset of T cells, gamma delta T cells detected at the site of inflammation, may be important in the pathogenesis of the disease. This study investigated variable (V) gene usage of gamma delta T cell receptors (TcRs) expressed in synovia and peripheral blood of patients with RA by using the polymerase chain reaction (PCR) to amplify TcR gamma- and delta-chain transcripts. Most patients showed no restriction in V gamma gene usage since synovial mononuclear cells (SMC) expressed TcR gamma-chain transcripts which used the same set of V gamma genes as peripheral blood mononuclear cells (PBMC). In contrast, the majority of patients expressed a restricted SMC V delta-chain repertoire biased towards V delta 1, but V delta 2 mRNA transcripts were also detected, albeit at low levels in some patients. The TcR delta-chain repertoires of PBMC from healthy control subjects were also characterized. There was variation in the TcR delta-chain repertoires of PBMC from patients when compared with controls, particularly with respect to expression of V delta 4. V delta 4 mRNA transcripts were expressed in PBMC of only two of seven RA patients in contrast with eight of the nine controls (P = 0.03). These findings are compatible with reports that gamma delta T cells in the rheumatoid synovium are reactive to Mycobacterium tuberculosis and that response to M. tuberculosis is restricted to V gamma 9/V delta 2-bearing T cells, if a superantigen is involved in the pathogenesis of RA.
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