ArticleBritish journal of cancer1992
Overexpression of the p53 protein and allele loss at 17p13 in ovarian carcinoma.
Article in British journal of cancer, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 93 citations in OpenAlex.
- Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis.Oncotarget · 2016Article
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- Atypical epithelial changes and mutant p53 gene expression in ovarian endometriosis.Pathology oncology research : POR · 2001Article
- Functional evidence for an ovarian cancer tumor suppressor gene on chromosome 22 by microcell-mediated chromosome transfer.Oncogene · 2000Article
- Allelotyping defines minimal imbalance at chromosomal region 17q25 in non-serous epithelial ovarian cancers.Oncogene · 2000Article
- p53 overexpression is associated with cytoreduction and response to chemotherapy in ovarian cancer.British journal of cancer · 1999Article
- p53 alterations are predictive of chemoresistance and aggressiveness in ovarian carcinomas: a molecular and immunohistochemical study.British journal of cancer · 1997Article
- Allele loss from large regions of chromosome 17 is common only in certain histological subtypes of ovarian carcinomas.British journal of cancer · 1996Article
- Synchronous colon carcinomas: molecular-genetic evidence for multicentricity.Annals of surgical oncology · 1996Article
- Immunostaining of p53 protein in ovarian carcinoma: correlation with histopathological data and clinical outcome.Journal of cancer research and clinical oncology · 1996Article
- Immunohistochemical profile of ovarian inclusion cysts in patients with and without ovarian carcinoma.The Histochemical journal · 1995Article
- Immunohistochemical analysis of p53 protein and 72 kDa heat shock protein (HSP72) expression in ovarian carcinomas. Correlation with clinicopathology and sex steroid receptor status.Virchows Archiv : an international journal of pathology · 1995Article
- Multiplex PCR screening detects small p53 deletions and insertions in human ovarian cancer cell lines.Human genetics · 1994Article
- Physical deletion of the p53 gene in bladder cancer. Detection by fluorescence in situ hybridization.The American journal of pathology · 1994Article
- p53 mutations in cervical carcinogenesis--low frequency and lack of correlation with human papillomavirus status.British journal of cancer · 1994Article
- Immunohistochemical study of p53 protein in human and animal pituitary tumors.Endocrine pathology · 1993Article
- p53 gene mutations and protein accumulation in human ovarian cancer.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Detection of p53 overexpression in routinely paraffin-embedded tissue of human carcinomas using a novel target unmasking fluid.The American journal of pathology · 1993Article
- Immunohistochemical analysis of p53 protein over-expression in endometrial carcinomas: inverse correlation with sex steroid receptor status.Virchows Archiv. A, Pathological anatomy and histopathology · 1993Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mouse monoclonal antibodies PAb 240 and PAb 1801 which specifically immunoprecipitate p53 protein, were used to examine 27 fresh ovarian tumours (16 serous adenocarcinomas, six endometrioid carcinomas, one mucinous adenocarcinoma, one mucinous borderline tumour and three benign adenomas). Eleven out of 16 (69%) serous adenocarcinomas and one endometrioid tumour showed positive staining with one or both antibodies and none of the mucinous or benign tumours stained with either antibody. DNA from tumour and peripheral blood leukocytes was used to identify allelic deletions on chromosome 17p in tumours. 11/12 positively staining tumours showed less of heterozygosity (LOH) on 17p at the nearest informative locus to the p53 gene. In this series of ovarian tumours, LOH on 17p correlates closely with the aberrant expression of the p53 protein in a high proportion of advanced stage serous adenocarcinomas. This observation suggests that the p53 tumour suppressor gene is involved in the evolution of epithelial ovarian cancer (EOC) and may have prognostic significance.
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